Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20475015 | 1.00 | TDP1 (0.42) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL24850183 | 1.00 | TDP1 (0.42) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL18729858 | 0.85 | TDP1 (0.40) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL18729861 | 0.85 | TDP1 (0.40) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL19689338 | 0.78 | TDP1 (0.44) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL19689337 | 0.78 | TDP1 (0.44) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL17838017 | 0.75 | TDP1 (0.50) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL17837383 | 0.75 | TDP1 (0.50) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL17768477 | 0.74 | TDP1 (0.40) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL24850184 | 0.74 | TDP1 (0.46) | TDP1KMT2AMAPK1HIF1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10441576-B2 | Substituted 1,2-dihydro-3H pyrrolo[1,2-c]imidazol-3 one antibacterials | IDORSIA PHARMACEUTICALS LTD. (CH) | 2019-10-15 | — | — | US | disclosed |
| EP-3334737-B1 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE ANTIBACTERIAL COMPOUNDS | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-10-09 | — | — | EP | disclosed |
| US-20180235938-A1 | SUBSTITUTED 1,2-DIHYDRO-3H PYRROLO[1,2-c]IMIDAZOL-3 ONE ANTIBACTERIALS | IDORSIA PHARMACEUTICALS LTD. (CH) | 2018-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180235938-A1 | SUBSTITUTED 1,2-DIHYDRO-3H PYRROLO[1,2-c]IMIDAZOL-3 ONE ANTIBACTERIALS | CTSH, MRPL21, CASP3 | TDP1 3309/4885KMT2A 3524/4885MAPK1 794/4885 |
| US-10441576-B2 | Substituted 1,2-dihydro-3H pyrrolo[1,2-c]imidazol-3 one antibacterials | CTSH, MRPL21, CASP3 | TDP1 3309/4885KMT2A 3524/4885MAPK1 794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.