Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19689338 | 1.00 | TDP1 (0.44) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL9836346 | 0.82 | TDP1 (0.46) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL24850183 | 0.78 | TDP1 (0.42) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL20475015 | 0.78 | TDP1 (0.42) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL20475014 | 0.78 | TDP1 (0.42) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL17837383 | 0.76 | TDP1 (0.50) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL17838017 | 0.76 | TDP1 (0.50) | TDP1KMT2AMAPK1HIF1ASLC6A2 | |
| SCHEMBL18729836 | 0.76 | CYP3A4 (0.39) | TDP1MAPK1HIF1ASLC6A3LMNA | |
| SCHEMBL30411073 | 0.76 | CYP3A4 (0.39) | TDP1MAPK1HIF1ASLC6A3LMNA | |
| SCHEMBL18498438 | 0.76 | CYP3A4 (0.39) | TDP1MAPK1HIF1ASLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10441576-B2 | Substituted 1,2-dihydro-3H pyrrolo[1,2-c]imidazol-3 one antibacterials | IDORSIA PHARMACEUTICALS LTD. (CH) | 2019-10-15 | — | — | US | disclosed |
| EP-3334737-B1 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE ANTIBACTERIAL COMPOUNDS | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-10-09 | — | — | EP | disclosed |
| EP-3221300-B1 | ANTIBACTERIAL BENZOTHIAZOLE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-03-20 | — | — | EP | disclosed |
| US-20190031676-A1 | ANTIBACTERIAL ANNULATED PYRROLIDIN-2-ONE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-01-31 | — | — | US | disclosed |
| US-20180251434-A1 | ANTIBACTERIAL HETEROCYCLIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2018-09-06 | — | — | US | disclosed |
| US-20180235938-A1 | SUBSTITUTED 1,2-DIHYDRO-3H PYRROLO[1,2-c]IMIDAZOL-3 ONE ANTIBACTERIALS | IDORSIA PHARMACEUTICALS LTD. (CH) | 2018-08-23 | — | — | US | disclosed |
| US-20170355687-A1 | ANTIBACTERIAL BENZOTHIAZOLE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180235938-A1 | SUBSTITUTED 1,2-DIHYDRO-3H PYRROLO[1,2-c]IMIDAZOL-3 ONE ANTIBACTERIALS | CTSH, MRPL21, CASP3 | TDP1 3309/4885KMT2A 3524/4885MAPK1 794/4885 |
| US-20190031676-A1 | ANTIBACTERIAL ANNULATED PYRROLIDIN-2-ONE DERIVATIVES | PYCR1, PSPH, RPSA | TDP1 4144/4885KMT2A 1491/4885MAPK1 700/4885 |
| US-10441576-B2 | Substituted 1,2-dihydro-3H pyrrolo[1,2-c]imidazol-3 one antibacterials | CTSH, MRPL21, CASP3 | TDP1 3309/4885KMT2A 3524/4885MAPK1 794/4885 |
| US-20170355687-A1 | ANTIBACTERIAL BENZOTHIAZOLE DERIVATIVES | CYP8B1, TUBB, DRD3 | TDP1 4087/4885KMT2A 482/4885MAPK1 2377/4885 |
| US-20180251434-A1 | ANTIBACTERIAL HETEROCYCLIC DERIVATIVES | MRPL21, DCXR, Q6ZSR9 | TDP1 4348/4885KMT2A 3564/4885MAPK1 2365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.