Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | PGK1 | P00558 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11689561 | 0.86 | ESR1 (0.61) | ESR1LMNAMAPTKMT2APGK1 | |
| SCHEMBL23588568 | 0.82 | ESR1 (0.40) | ESR1LMNAMAPTKMT2ACYP1A2 | |
| SCHEMBL10093922 | 0.80 | ESR1 (0.50) | ESR1LMNAMAPTKMT2APGK1 | |
| SCHEMBL12309955 | 0.79 | NOS3 (0.43) | ESR1LMNAMAPTKMT2AFABP4 | |
| SCHEMBL28230769 | 0.79 | ESR1 (0.39) | ESR1LMNAMAPTKMT2ACYP1A2 | |
| SCHEMBL20476323 | 0.78 | MAPT (0.50) | ESR1LMNAMAPTKMT2APGK1 | |
| SCHEMBL9842958 | 0.77 | ESR1 (0.38) | ESR1KMT2ACYP1A2ESR2 | |
| SCHEMBL2623105 | 0.74 | ESR1 (0.42) | ESR1PGK1KCNH2CACNA1CSCN5A | |
| SCHEMBL11364615 | 0.74 | ESR1 (0.44) | ESR1LMNAMAPTKMT2APGK1 | |
| SCHEMBL25145081 | 0.73 | LMNA (0.44) | ESR1LMNAMAPTKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078165-B2 | Compounds for treating tuberculosis | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2021-08-03 | — | — | US | disclosed |
| US-20200231550-A1 | COMPOUNDS FOR TREATING TUBERCULOSIS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2020-07-23 | — | — | US | disclosed |
| WO-2018151681-A1 | COMPOUNDS FOR TREATING TUBERCULOSIS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2018-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078165-B2 | Compounds for treating tuberculosis | ATP5ME, ATP5MG, ATP5F1D | ESR1 2488/4885LMNA 3226/4885MAPT 2750/4885 |
| US-20200231550-A1 | COMPOUNDS FOR TREATING TUBERCULOSIS | ATP5ME, ATP5MG, ATP5F1D | ESR1 2488/4885LMNA 3226/4885MAPT 2750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.