Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 19/20 | 0.88 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.88 |
| ▸ | LIMK2 | P53671 | 4/20 | 0.88 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.88 |
| ▸ | CDC7 | O00311 | 3/20 | 0.88 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.88 |
| ▸ | PLK4 | O00444 | 3/20 | 0.88 |
| ▸ | CIT | O14578 | 3/20 | 0.88 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.88 |
| ▸ | IKBKB | O14920 | 3/20 | 0.88 |
| ▸ | CASK | O14936 | 3/20 | 0.88 |
| ▸ | AURKA | O14965 | 3/20 | 0.88 |
| ▸ | GAK | O14976 | 3/20 | 0.88 |
| ▸ | MAST4 | O15021 | 3/20 | 0.88 |
| ▸ | CHUK | O15111 | 3/20 | 0.88 |
| ▸ | MUSK | O15146 | 3/20 | 0.88 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.88 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.88 |
| ▸ | MAP3K13 | O43283 | 3/20 | 0.88 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tp-030-1 SCHEMBL20477342 | 0.94 | RIPK1 (1.00) | RIPK1LIMK1LIMK2BMPR1BCDC7 | |
| SCHEMBL20477351 | 0.92 | RIPK1 (1.00) | RIPK1LIMK1LIMK2BMPR1BCDC7 | |
| SCHEMBL20477413 | 0.92 | RIPK1 (0.86) | RIPK1LIMK1LIMK2BMPR1BCDC7 | |
| SCHEMBL20477237 | 0.91 | RIPK1 (0.84) | RIPK1LIMK1LIMK2BMPR1BCDC7 | |
| SCHEMBL20477292 | 0.90 | RIPK1 (0.83) | RIPK1LIMK1LIMK2BMPR1BCDC7 | |
| SCHEMBL20477297 | 0.90 | RIPK1 (0.83) | RIPK1LIMK1LIMK2BMPR1BCDC7 | |
| SCHEMBL20477355 | 0.89 | RIPK1 (0.81) | RIPK1LIMK1LIMK2BMPR1BCDC7 | |
| SCHEMBL20477427 | 0.89 | RIPK1 (0.84) | RIPK1LIMK1LIMK2BMPR1BCDC7 | |
| SCHEMBL20477387 | 0.88 | RIPK1 (0.82) | RIPK1LIMK1LIMK2BMPR1BCDC7 | |
| SCHEMBL20477350 | 0.87 | RIPK1 (0.84) | RIPK1LIMK1LIMK2BMPR1BCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787462-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-09-29 | — | — | US | disclosed |
| EP-3366684-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2020-09-02 | — | — | EP | disclosed |
| EP-3366684-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-08-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787462-B2 | Heterocyclic compound | RIPK1, RIPK4, RIPK3 | RIPK1 1/4885LIMK1 1608/4885LIMK2 2405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.