Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.53 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.53 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.53 |
| ▸ | ITGAV | P06756 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8852192 | 0.86 | SLC1A3 (0.50) | SLC1A3SLC1A2SLC1A1ITGAVALDH1A1 | |
| SCHEMBL9001208 | 0.85 | SLC1A3 (0.55) | SLC1A3SLC1A2SLC1A1ITGAVALDH1A1 | |
| SCHEMBL8851832 | 0.83 | SLC1A3 (0.54) | SLC1A3SLC1A2SLC1A1ITGAVALDH1A1 | |
| SCHEMBL4588941 | 0.78 | SLC1A3 (0.74) | SLC1A3SLC1A2SLC1A1ITGAVALDH1A1 | |
| SCHEMBL3964633 | 0.78 | SLC1A3 (0.74) | SLC1A3SLC1A2SLC1A1ITGAVALDH1A1 | |
| SCHEMBL23518183 | 0.77 | SLC1A3 (0.49) | SLC1A3SLC1A2SLC1A1ITGAVALDH1A1 | |
| SCHEMBL8851519 | 0.77 | SLC1A3 (0.49) | SLC1A3SLC1A2SLC1A1ITGAVALDH1A1 | |
| SCHEMBL13951132 | 0.77 | SLC1A3 (0.54) | SLC1A3SLC1A2SLC1A1ALDH1A1LMNA | |
| SCHEMBL8851493 | 0.77 | SLC1A3 (0.49) | SLC1A3SLC1A2SLC1A1ITGAVALDH1A1 | |
| SCHEMBL14798294 | 0.77 | SLC1A3 (0.64) | SLC1A3SLC1A2SLC1A1ITGAVALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180243297-A1 | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors | NOVARTIS AG (CH) | 2018-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180243297-A1 | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors | PI4KA, PIP5K1B, PIP4K2B | SLC1A3 1789/4885SLC1A2 2404/4885SLC1A1 1871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.