Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FABP7 | O15540 | 1/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20478857 | 0.87 | TAS1R3 (0.45) | TAS1R3TAS1R1TAS1R2P2RX7ALDH1A1 | |
| SCHEMBL15129434 | 0.87 | TAS1R3 (0.45) | TAS1R3TAS1R1TAS1R2P2RX7ALDH1A1 | |
| SCHEMBL3900421 | 0.81 | TAS1R3 (0.45) | TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL9055286 | 0.81 | HTT (0.36) | ALDH1A1 | |
| SCHEMBL7537910 | 0.81 | KDM4E (0.39) | TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL20478916 | 0.78 | HTT (0.43) | TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL20478656 | 0.77 | DRD4 (0.50) | TAS1R3TAS1R1 | |
| SCHEMBL16395440 | 0.77 | P2RX7 (0.42) | TAS1R3TAS1R1TAS1R2P2RX7NOTUM | |
| SCHEMBL16395306 | 0.77 | P2RX7 (0.42) | TAS1R3TAS1R1TAS1R2P2RX7NOTUM | |
| SCHEMBL15129413 | 0.77 | P2RX7 (0.42) | TAS1R3TAS1R1TAS1R2P2RX7NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180244611-A1 | Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use | ABBVIE S.Á.R.L. (LU) | 2018-08-30 | — | — | US | disclosed |
| WO-2018154519-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie S.à.r.l. (LU) | 2018-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180244611-A1 | Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use | CFTR, CLCN2, SCNN1G | TAS1R3 756/4885TAS1R1 738/4885TAS1R2 624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.