SCHEMBL20482190

SCHEMBL20482190

CNC(C)c1ccc(C(N)=NO)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
RAB9A P51151 3/20 0.41
GAA P10253 2/20 0.41
KDM1A O60341 2/20 0.41
LMNA P02545 3/20 0.39
KMT2A Q03164 2/20 0.39
GFER P55789 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
NPC1 O15118 2/20 0.38
TP53 P04637 2/20 0.38
MAPT P10636 1/20 0.38
ALOX15 P16050 1/20 0.38
HSD17B10 Q99714 1/20 0.38
RECQL P46063 1/20 0.38
HTT P42858 1/20 0.37
HDAC1 Q13547 3/20 0.37
HDAC2 Q92769 3/20 0.37
F10 P00742 1/20 0.37
MEN1 O00255 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20482189 1.00 ALDH1A1 (0.44) ALDH1A1RAB9AGAAKDM1ALMNA
SCHEMBL1505344 0.80 HTT (0.57) ALDH1A1RAB9AGAAKDM1ALMNA
SCHEMBL1505342 0.80 HTT (0.57) ALDH1A1RAB9AGAAKDM1ALMNA
SCHEMBL12900245 0.80 HTT (0.57) ALDH1A1RAB9AGAAKDM1ALMNA
SCHEMBL3122189 0.80 NR1H4 (0.43) ALDH1A1LMNAKMT2AGFERL3MBTL1
SCHEMBL12505626 0.80 NR1H4 (0.43) ALDH1A1LMNAKMT2AGFERL3MBTL1
SCHEMBL3122198 0.80 NR1H4 (0.43) ALDH1A1LMNAKMT2AGFERL3MBTL1
SCHEMBL12505589 0.80 NR1H4 (0.43) ALDH1A1LMNAKMT2AGFERL3MBTL1
SCHEMBL12505588 0.80 NR1H4 (0.43) ALDH1A1LMNAKMT2AGFERL3MBTL1
SCHEMBL12505587 0.80 NR1H4 (0.43) ALDH1A1LMNAKMT2AGFERL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11425910-B2 Substituted oxadiazoles for combating phytopathogenic fungi BASF SE (DE) 2022-08-30 US disclosed
US-20210137115-A1 Substituted Oxadiazoles for Combating Phytopathogenic Fungi BASF SE (DE) 2021-05-13 US disclosed
EP-3585773-B1 SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2021-04-07 EP disclosed
US-10674727-B2 Substituted oxadiazoles for combating phytopathogenic fungi BASF SE (DE) 2020-06-09 US disclosed
US-20180368409-A1 SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2018-12-27 US disclosed
EP-3376868-A1 SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2018-09-26 EP disclosed
WO-2018153730-A1 SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2018-08-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10674727-B2 Substituted oxadiazoles for combating phytopathogenic fungi CYP51A1, FOXO3, NOXO1 ALDH1A1 666/4885RAB9A 4736/4885GAA 757/4885
US-11425910-B2 Substituted oxadiazoles for combating phytopathogenic fungi CYP51A1, DPM1, TH ALDH1A1 2017/4885RAB9A 4412/4885GAA 1070/4885
US-20210137115-A1 Substituted Oxadiazoles for Combating Phytopathogenic Fungi CYP51A1, DPM1, TH ALDH1A1 2017/4885RAB9A 4412/4885GAA 1070/4885
US-20180368409-A1 SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI CYP51A1, FOXO3, NOXO1 ALDH1A1 666/4885RAB9A 4736/4885GAA 757/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.