Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 17/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 17/20 | 0.45 |
| ▸ | ADK | P55263 | 2/20 | 0.42 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20488516 | 0.91 | PRMT5 (0.46) | PRMT5WDR77ADKMETTL3 | |
| SCHEMBL24314271 | 0.85 | ADK (0.43) | PRMT5WDR77ADKMETTL3 | |
| SCHEMBL29610855 | 0.85 | ADK (0.43) | PRMT5WDR77ADKMETTL3 | |
| SCHEMBL19667337 | 0.85 | PRMT5 (0.51) | PRMT5WDR77 | |
| SCHEMBL20487809 | 0.82 | PRMT5 (0.56) | PRMT5WDR77 | |
| SCHEMBL20487811 | 0.82 | PRMT5 (0.56) | PRMT5WDR77 | |
| SCHEMBL30941168 | 0.81 | ADK (0.46) | ADKMETTL3 | |
| SCHEMBL25046663 | 0.79 | ADK (0.46) | ADKMETTL3 | |
| SCHEMBL31617994 | 0.79 | ADK (0.44) | PRMT5WDR77ADKMETTL3 | |
| SCHEMBL25048642 | 0.77 | ADK (0.42) | ADKMETTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018160824-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2018-09-07 | — | — | WO | disclosed |