Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15445432 | 0.84 | KMT2A (0.64) | MEN1KMT2AKDM4EPKMMAPT | |
| SCHEMBL23564828 | 0.84 | KDM4E (0.50) | MEN1KMT2AKDM4EPKMMAPT | |
| SCHEMBL10465977 | 0.84 | HTT (0.55) | MEN1KMT2AKDM4EPKMMAPT | |
| SCHEMBL5514790 | 0.83 | KDM4E (0.50) | MEN1KMT2AKDM4EPKMMAPT | |
| SCHEMBL5777181 | 0.83 | KDM4E (0.49) | MEN1KMT2AKDM4EPKMMAPT | |
| SCHEMBL14472404 | 0.81 | HTT (0.51) | MEN1KMT2AKDM4EPKMMAPT | |
| SCHEMBL15445433 | 0.81 | SMN1; SMN2 (0.50) | MEN1KMT2AKDM4EPKMMAPT | |
| SCHEMBL25082365 | 0.81 | ALDH1A1 (0.55) | MEN1KMT2AKDM4EPKMMAPT | |
| SCHEMBL15184726 | 0.81 | MMP1 (0.46) | MEN1KMT2AKDM4EPKMMAPT | |
| SCHEMBL20689 | 0.80 | PDE4B (0.49) | MEN1KMT2APKMMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11248007-B2 | Inhibitors of MALT1 and uses thereof | CORNELL UNIVERSITY (US) | 2022-02-15 | — | — | US | disclosed |
| US-11248007-B2 | Inhibitors of MALT1 and uses thereof | CORNELL UNIVERSITY (US) | 2022-02-15 | — | — | US | disclosed |
| US-20200385405-A1 | INHIBITORS OF MALT1 AND USES THEREOF | CORNELL UNIVERSITY (US) | 2020-12-10 | — | — | US | disclosed |
| US-20200385405-A1 | INHIBITORS OF MALT1 AND USES THEREOF | CORNELL UNIVERSITY (US) | 2020-12-10 | — | — | US | disclosed |
| WO-2018165385-A1 | INHIBITORS OF MALT1 AND USES THEREOF | CORNELL UNIVERSITY (US) | 2018-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200385405-A1 | INHIBITORS OF MALT1 AND USES THEREOF | MALT1, BCL6, BCL3 | MEN1 2523/4885KMT2A 2359/4885KDM4E 1844/4885 |
| US-11248007-B2 | Inhibitors of MALT1 and uses thereof | MALT1, BCL6, BCL3 | MEN1 2523/4885KMT2A 2359/4885KDM4E 1844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.