Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 17/20 | 0.69 |
| ▸ | ERBB2 known ✓ | P04626 | 9/20 | 0.64 |
| ▸ | ERBB4 known ✓ | Q15303 | 5/20 | 0.61 |
| ▸ | JAK3 known ✓ | P52333 | 2/20 | 0.61 |
| ▸ | BTK known ✓ | Q06187 | 1/20 | 0.61 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.59 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.59 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.59 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 4/20 | 0.61 |
| ▸ | KIT | P10721 | 2/20 | 0.61 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.61 |
| ▸ | GAK | O14976 | 2/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.61 |
| ▸ | LCK | P06239 | 2/20 | 0.61 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.61 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.61 |
| ▸ | CIT | O14578 | 1/20 | 0.61 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.61 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL18138483 | 1.00 | EGFR (0.69) | EGFRERBB2ERBB4SRCKIT | |
| Fumaric Acid SCHEMBL18138485 | 1.00 | EGFR (0.69) | EGFRERBB2ERBB4SRCKIT | |
| SCHEMBL16809094 | 0.97 | EGFR (0.71) | EGFRERBB2ERBB4SRCKIT | |
| Oxalic Acid SCHEMBL20496149 | 0.96 | EGFR (0.69) | EGFRERBB2ERBB4SRCKIT | |
| Acetic Acid SCHEMBL20496158 | 0.96 | EGFR (0.69) | EGFRERBB2ERBB4SRCKIT | |
| Hydrochloric Acid SCHEMBL18138465 | 0.96 | EGFR (0.70) | EGFRERBB2ERBB4SRCKIT | |
| Bromide SCHEMBL18138475 | 0.96 | EGFR (0.70) | EGFRERBB2ERBB4SRCKIT | |
| Propionic Acid SCHEMBL18138467 | 0.95 | EGFR (0.69) | EGFRERBB2ERBB4SRCKIT | |
| Phosphoric Acid SCHEMBL18138470 | 0.95 | EGFR (0.69) | EGFRERBB2ERBB4SRCKIT | |
| Cadaverine Tartrate SCHEMBL20496150 | 0.94 | EGFR (0.66) | EGFRERBB2ERBB4SRCKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3081563-B1 | QUINAZOLINE DERIVATIVE AND SALTS THEREOF FOR USE IN THE TREATMENT OF CANCER | TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO LTD (CN) | 2018-09-19 | — | — | EP | claimed |