Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 3/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.41 |
| ▸ | PARP1 | P09874 | 6/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22135686 | 0.86 | PARP10 (0.41) | EZH2PARP10PARP1F7F3 | |
| SCHEMBL15813600 | 0.85 | RORC (0.38) | EZH2PARP10PARP1F7F3 | |
| SCHEMBL15814394 | 0.85 | EZH2 (0.42) | EZH2S1PR1HTR2AKMO | |
| SCHEMBL15813822 | 0.84 | EZH2 (0.45) | EZH2PARP10PARP1F7F3 | |
| SCHEMBL15813555 | 0.84 | HTR2C (0.53) | EZH2PARP10PARP1F7F3 | |
| SCHEMBL20499757 | 0.77 | EZH2 (0.43) | EZH2PARP10PARP1F7F3 | |
| SCHEMBL15813994 | 0.75 | HTR2C (0.47) | EZH2PARP10PARP1F7F3 | |
| SCHEMBL15830714 | 0.75 | PARP10 (0.47) | PARP10PARP1F7F3LCK | |
| SCHEMBL15814505 | 0.75 | S1PR1 (0.34) | PARP10PARP1F7F3S1PR1 | |
| SCHEMBL15815035 | 0.74 | KDM4E (0.36) | EZH2PARP10PARP1F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266542-B2 | EZH2 inhibitors | Mirati Therapeutics, Inc. (US) | 2019-04-23 | — | — | US | disclosed |
| US-10266542-B2 | EZH2 inhibitors | Mirati Therapeutics, Inc. (US) | 2019-04-23 | — | — | US | disclosed |
| US-20180265517-A1 | EZH2 Inhibitors | Mirati Therapeutics, Inc. | 2018-09-20 | — | — | US | disclosed |
| US-9255104-B2 | Cyclopropyl modulators of P2Y12 receptor | AUSPEX PHARMACEUTICALS, INC. (US) | 2016-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180265517-A1 | EZH2 Inhibitors | EZH2, BMI1, EED | EZH2 1/4885PARP10 229/4885PARP1 312/4885 |
| US-10266542-B2 | EZH2 inhibitors | EZH2, BMI1, EED | EZH2 1/4885PARP10 229/4885PARP1 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.