Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15815035 | 0.88 | KDM4E (0.36) | EZH2KDM4EALDH1A1POLBHPGD | |
| SCHEMBL15830735 | 0.84 | KDM4E (0.36) | EZH2KDM4EALDH1A1POLBHPGD | |
| SCHEMBL15814278 | 0.84 | NCOA1 (0.43) | KDM4EALDH1A1HPGDNOTUMHTT | |
| SCHEMBL15814409 | 0.82 | EED (0.36) | EZH2KDM4EALDH1A1POLBHPGD | |
| SCHEMBL15815050 | 0.81 | EED (0.35) | EZH2KDM4EALDH1A1POLBHPGD | |
| SCHEMBL16821944 | 0.78 | EZH2 (0.31) | EZH2KDM4EALDH1A1POLBHPGD | |
| SCHEMBL15830727 | 0.77 | P2RX3 (0.37) | EZH2PARP1 | |
| SCHEMBL20499628 | 0.77 | EZH2 (0.45) | EZH2KDM4EALDH1A1POLBHPGD | |
| SCHEMBL15814178 | 0.75 | NCOA1 (0.41) | KDM4EALDH1A1HPGDHTTPTK2B | |
| SCHEMBL15830723 | 0.75 | PARP10 (0.44) | KDM4EALDH1A1NOTUMHTTPTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266542-B2 | EZH2 inhibitors | Mirati Therapeutics, Inc. (US) | 2019-04-23 | — | — | US | disclosed |
| US-10266542-B2 | EZH2 inhibitors | Mirati Therapeutics, Inc. (US) | 2019-04-23 | — | — | US | disclosed |
| US-20180265517-A1 | EZH2 Inhibitors | Mirati Therapeutics, Inc. | 2018-09-20 | — | — | US | disclosed |
| US-9255104-B2 | Cyclopropyl modulators of P2Y12 receptor | AUSPEX PHARMACEUTICALS, INC. (US) | 2016-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180265517-A1 | EZH2 Inhibitors | EZH2, BMI1, EED | EZH2 1/4885KDM4E 27/4885ALDH1A1 1969/4885 |
| US-10266542-B2 | EZH2 inhibitors | EZH2, BMI1, EED | EZH2 1/4885KDM4E 27/4885ALDH1A1 1969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.