Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.50 |
| ▸ | POLRMT | O00411 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.31 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.31 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.31 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.31 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.31 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25378413 | 1.00 | TMPRSS2 (0.50) | TMPRSS2POLRMTSIRT2SIRT1P2RY1 | |
| SCHEMBL18298281 | 0.94 | TMPRSS2 (0.51) | TMPRSS2POLRMTSIRT2SIRT1P2RY1 | |
| SCHEMBL17719237 | 0.93 | TMPRSS2 (0.50) | TMPRSS2POLRMTSIRT2SIRT1P2RY1 | |
| SCHEMBL24538669 | 0.91 | TMPRSS2 (0.49) | TMPRSS2POLRMTSIRT2SIRT1P2RY1 | |
| SCHEMBL26326132 | 0.91 | TMPRSS2 (0.49) | TMPRSS2POLRMTSIRT2SIRT1P2RY1 | |
| SCHEMBL17719238 | 0.89 | POLRMT (0.48) | TMPRSS2POLRMT | |
| SCHEMBL24917304 | 0.89 | TMPRSS2 (0.47) | TMPRSS2POLRMTP2RY1SRCP2RY2 | |
| Rdv-Tp SCHEMBL23278555 | 0.88 | POLRMT (0.51) | TMPRSS2POLRMTP2RY1 | |
| Rdv-Tp SCHEMBL10120881 | 0.88 | POLRMT (0.51) | TMPRSS2POLRMTP2RY1 | |
| Rdv-Tp SCHEMBL24492746 | 0.88 | POLRMT (0.51) | TMPRSS2POLRMTP2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4331677-A2 | METHODS OF TREATING FELINE CORONAVIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| EP-3595672-B1 | COMPOUNDS FOR USE IN METHODS OF TREATING FELINE CORONAVIRUS INFECTIONS | GILEAD SCIENCES INC (US) | 2023-09-06 | — | — | EP | disclosed |
| US-11260070-B2 | Methods of treating feline coronavirus infections | GILEAD SCIENCES, INC. (US) | 2022-03-01 | — | — | US | disclosed |
| US-20200376014-A1 | METHODS OF TREATING FELINE CORONAVIRUS INFECTIONS | GILEAD SCIENCES, INC. | 2020-12-03 | — | — | US | disclosed |
| US-10682368-B2 | Methods of treating feline coronavirus infections | GILEAD SCIENCES, INC. (US) | 2020-06-16 | — | — | US | disclosed |
| US-20180296584-A1 | METHODS OF TREATING FELINE CORONAVIRUS INFECTIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2018-10-18 | — | — | US | disclosed |
| WO-2018169946-A1 | METHODS OF TREATING FELINE CORONAVIRUS INFECTIONS | GILEAD SCIENCES, INC. (US) | 2018-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11260070-B2 | Methods of treating feline coronavirus infections | SARS1, CPN1, CAT | TMPRSS2 62/4885POLRMT 36/4885SIRT2 2983/4885 |
| US-20180296584-A1 | METHODS OF TREATING FELINE CORONAVIRUS INFECTIONS | CAT, ACE, ACE2 | TMPRSS2 11/4885POLRMT 986/4885SIRT2 3244/4885 |
| US-10682368-B2 | Methods of treating feline coronavirus infections | SARS1, CPN1, CAT | TMPRSS2 62/4885POLRMT 36/4885SIRT2 2983/4885 |
| US-20200376014-A1 | METHODS OF TREATING FELINE CORONAVIRUS INFECTIONS | CAT, ACE, ACE2 | TMPRSS2 9/4885POLRMT 860/4885SIRT2 3190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.