Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 18/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.42 |
| ▸ | MAP3K6 | O95382 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20501035 | 1.00 | MAP3K5 (0.58) | MAP3K5MAP3K7MAP3K6RETCDK2 | |
| SCHEMBL20523136 | 0.86 | MAP3K5 (0.58) | MAP3K5MAP3K7MAP3K6CDK2 | |
| SCHEMBL29217677 | 0.86 | MAP3K5 (0.58) | MAP3K5MAP3K7MAP3K6CDK2 | |
| SCHEMBL30269941 | 0.86 | MAP3K5 (0.58) | MAP3K5MAP3K7MAP3K6CDK2 | |
| SCHEMBL20523134 | 0.86 | MAP3K5 (0.58) | MAP3K5MAP3K7MAP3K6CDK2 | |
| SCHEMBL21715722 | 0.86 | MAP3K5 (0.44) | MAP3K5RETCDK2ITKMERTK | |
| SCHEMBL15136088 | 0.84 | MAP3K5 (0.56) | MAP3K5MAP3K7MAP3K6RETCDK2 | |
| SCHEMBL29506348 | 0.84 | MAP3K5 (0.56) | MAP3K5MAP3K7MAP3K6RETCDK2 | |
| SCHEMBL23064273 | 0.84 | MAP3K5 (0.52) | MAP3K5MAP3K7MAP3K6MAP4K1 | |
| SCHEMBL20802747 | 0.84 | MAP3K5 (0.60) | MAP3K5MAP3K7MAP3K6CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018169742-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBTOR | GILEAD SCIENCES, INC. (US) | 2018-09-20 | — | — | WO | disclosed |