Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 20/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.54 |
| ▸ | MAP3K6 | O95382 | 4/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30269941 | 1.00 | MAP3K5 (0.58) | MAP3K5MAP3K7MAP3K6CCNA2CCNE1 | |
| SCHEMBL20523134 | 1.00 | MAP3K5 (0.58) | MAP3K5MAP3K7MAP3K6CCNA2CCNE1 | |
| SCHEMBL29217677 | 1.00 | MAP3K5 (0.58) | MAP3K5MAP3K7MAP3K6CCNA2CCNE1 | |
| SCHEMBL20802806 | 0.90 | MAP3K5 (0.49) | MAP3K5MAP3K7MAP3K6CCNA2CCNE1 | |
| SCHEMBL20802747 | 0.90 | MAP3K5 (0.60) | MAP3K5MAP3K7MAP3K6CCNA2CCNE1 | |
| SCHEMBL28369638 | 0.90 | MAP3K5 (0.60) | MAP3K5MAP3K7MAP3K6CCNA2CCNE1 | |
| SCHEMBL20802849 | 0.87 | MAP3K5 (0.53) | MAP3K5MAP3K7MAP3K6CCNA2CCNE1 | |
| SCHEMBL20802753 | 0.87 | MAP3K5 (0.53) | MAP3K5MAP3K7MAP3K6CCNA2CCNE1 | |
| SCHEMBL20501037 | 0.86 | MAP3K5 (0.58) | MAP3K5MAP3K7MAP3K6CDK2 | |
| SCHEMBL20501035 | 0.86 | MAP3K5 (0.58) | MAP3K5MAP3K7MAP3K6CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117903128-A | ASK1/PDK1 double-targeting inhibitor, and preparation method and application thereof | 中南大学 | 2024-04-19 | — | — | CN | disclosed |
| CN-117756785-A | Preparation and application of N- (pyridine-2-yl) benzo [ b ] five-membered heterocycle-3-carboxamide structure compound | 江西中医药大学 | 2024-03-26 | — | — | CN | disclosed |
| CN-116874468-A | Synthesis and application of small molecular compound with 2-pyridine substituted formamide structure | 江西中医药大学 | 2023-10-13 | — | — | CN | disclosed |
| CN-110818683-B | 2-pyridine substituted urea structure small molecule compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2023-04-14 | — | — | CN | disclosed |
| US-11345676-B2 | Apoptosis signal-regulating kinase 1 (ASK 1) inhibitor compounds | PHARMAKEA, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| US-11345699-B2 | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| CN-109071498-B | Kinase inhibitor and preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2021-03-30 | — | — | CN | disclosed |
| US-20200157095-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2020-05-21 | — | — | US | disclosed |
| CN-110818683-A | 2-pyridine substituted urea structure small molecule compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2020-02-21 | — | — | CN | disclosed |
| US-20200048218-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS | PHARMAKEA, INC. | 2020-02-13 | — | — | US | disclosed |
| EP-3601250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS | Pharmakea, Inc. (US) | 2020-02-05 | — | — | EP | disclosed |
| US-10450301-B2 | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| US-20180362503-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-12-20 | — | — | US | disclosed |
| WO-2018218051-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-11-29 | — | — | WO | disclosed |
| WO-2018183122-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS | SIDECAR THERAPEUTICS, INC. (US) | 2018-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180362503-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF | BAD, AIFM1, BCL2 | MAP3K5 46/4885MAP3K7 48/4885MAP3K6 38/4885 |
| US-10450301-B2 | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | BAD, AIFM1, BCL2 | MAP3K5 46/4885MAP3K7 48/4885MAP3K6 38/4885 |
| US-20200048218-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS | BAX, BAD, BCL2 | MAP3K5 13/4885MAP3K7 16/4885MAP3K6 10/4885 |
| US-11345699-B2 | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | BAD, AIFM1, BCL2 | MAP3K5 46/4885MAP3K7 48/4885MAP3K6 38/4885 |
| US-20200157095-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF | BAD, AIFM1, BCL2 | MAP3K5 46/4885MAP3K7 48/4885MAP3K6 38/4885 |
| US-11345676-B2 | Apoptosis signal-regulating kinase 1 (ASK 1) inhibitor compounds | BAX, BAD, BCL2 | MAP3K5 13/4885MAP3K7 16/4885MAP3K6 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.