Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.55 |
| ▸ | PREP | P48147 | 3/20 | 0.48 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8244528 | 0.97 | SIGMAR1 (0.59) | TMEM97SIGMAR1PREPAADAT | |
| SCHEMBL206206 | 0.88 | TMEM97 (0.56) | TMEM97SIGMAR1PREPAADATALDH1A1 | |
| SCHEMBL24619724 | 0.85 | GAA (0.43) | TMEM97SIGMAR1ALDH1A1TSHR | |
| SCHEMBL205427 | 0.85 | TMEM97 (0.53) | TMEM97SIGMAR1PREPAADATALDH1A1 | |
| SCHEMBL4968298 | 0.85 | SIGMAR1 (0.60) | TMEM97SIGMAR1PREPAADAT | |
| SCHEMBL2379314 | 0.84 | TMEM97 (0.60) | TMEM97SIGMAR1PREPAADATKDM1A | |
| SCHEMBL206142 | 0.84 | TMEM97 (0.52) | TMEM97SIGMAR1PREPAADATALDH1A1 | |
| SCHEMBL16980525 | 0.82 | TMEM97 (0.56) | TMEM97SIGMAR1PREPAADATALDH1A1 | |
| SCHEMBL8248090 | 0.81 | TMEM97 (0.55) | TMEM97SIGMAR1PREPAADATALDH1A1 | |
| SCHEMBL26985411 | 0.80 | RIPK1 (0.45) | KDM1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088760-B2 | Benzoxazole carboxamide inhibitors of poly(ADP-ribose)polymerase (PARP) | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |
| US-20090197863-A1 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197863-A1 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | PARP1, PARP2, PARP11 | TMEM97 4001/4885SIGMAR1 4024/4885PREP 419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.