⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28358159 | 0.91 | ALDH1A1 (0.48) | — | |
| SCHEMBL4726387 | 0.78 | — | — | |
| SCHEMBL203356 | 0.77 | — | — | |
| SCHEMBL5803814 | 0.76 | — | — | |
| SCHEMBL2851032 | 0.76 | — | — | |
| SCHEMBL4912594 | 0.74 | — | — | |
| SCHEMBL10755499 | 0.73 | GAA (0.42) | — | |
| SCHEMBL8588543 | 0.71 | HCAR2 (0.50) | — | |
| SCHEMBL717594 | 0.71 | GAA (0.42) | — | |
| SCHEMBL11486594 | 0.70 | GAA (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1421 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106459024-B | Cyclopropyl amine compounds and application thereof | 武田药品工业株式会社 | 2019-11-05 | — | — | CN | claimed |
| CN-104926801-B | Substituted azetidine analog derivative, the pharmaceutical composition containing it and its application in antitumor | 浙江大学 | 2019-06-04 | — | — | CN | claimed |
| CN-108884066-A | The thiophene compound that new 2,3,5- as kinases inhibitor replace | 韩国科学技术研究院 | 2018-11-23 | — | — | CN | claimed |
| CN-104926788-B | Substituted piperidine analog derivative, the pharmaceutical composition containing it and its application in antitumor | 浙江大学 | 2018-08-28 | — | — | CN | claimed |
| CN-105283443-B | Hete rocyclic derivatives and application thereof | 株式会社C&C新药研究所 | 2018-08-17 | — | — | CN | claimed |
| CN-105121432-B | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-08-03 | — | — | CN | claimed |
| CN-106459024-A | Cyclopropanamine compound and use thereof | 武田药品工业株式会社 | 2017-02-22 | — | — | CN | claimed |
| EP-1348706-B1 | SUBSTITUTED THIAZOLE DERIVATIVES BEARING 3-PYRIDYL GROUPS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2009-08-19 | — | — | EP | claimed |
| US-20090099157-A1 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | claimed |
| WO-2008100621-A2 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | claimed |
| WO-2006122931-A1 | BETA-CARBOLINE DERIVATIVES AND THERI USE AS GHSR MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2006-11-23 | — | — | WO | claimed |
| US-20050288316-A1 | Beta-carbolines as growth hormone secretagogue receptor (GHSR) antagonists | BIOVITRUM AB (SE) | 2005-12-29 | — | — | US | claimed |
| WO-2005048916-A2 | TETRAHYDROSPIRO-BETA-CARBOLINE-1,3 '-PYRROLIDINE DERIVATIVES AND THEIR USE IN GHSR-RELATED DISORDERS | BIOVITRUM AB (SE) | 2005-06-02 | — | — | WO | claimed |
| US-6583146-B1 | Adenosine A3 receptor antagonist; asthma; 5-amino-3-(4-methoxyphenyl)-2-(4-pyridyl)-7H-thiazolo(3,2-a) pyrimidin-7-one | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-06-24 | — | — | US | claimed |
| US-5919928-A | Phenanthridine derivatives and metal complexes thereof used for transparent recording medium or optical recording medium | NIPPON PAPER INDUSTRIES, CO., LTD. (JP) | 1999-07-06 | — | — | US | claimed |
| US-5892042-A | OPTICAL RECORDING MEDIA WITH ACRIDINE DYES ON TRANSPARENT SUBSTRATE | NIPPON PAPER INDUSTRIES CO., LTD. (JP) | 1999-04-06 | — | — | US | claimed |
| US-5792863-A | HAVING LARGE ABSORPTION IN NEAR INFRARED, REDUCED ABSORPTION IN VISIBLE RANGE | NIPPON PAPER INDUSTRIES CO., LTD. (JP) | 1998-08-11 | — | — | US | claimed |
| EP-0705835-A1 | Quinoxalic-2,3-diones with an oxa or thiaheterocyclic fused ring | CIBA-GEIGY AG (CH) | 1996-04-10 | — | — | EP | claimed |
| EP-0078860-A1 | New 5-(N-alkyl-N-acyl-amino)-thiophen-2-carboxylic acid derivatives, process for producing the same and pharmaceutical compounds containing the same | A. Nattermann & Cie. GmbH (DE) | 1983-05-18 | — | — | EP | claimed |
| US-4242452-A | ENZYMATIC HYDROLYSIS OF 5-(2- OR 3-THIENYL)HYDANTOIN | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1980-12-30 | — | — | US | claimed |