⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL205040 | 0.77 | — | — | |
| SCHEMBL11054831 | 0.75 | GAA (0.64) | — | |
| SCHEMBL12060256 | 0.70 | — | — | |
| SCHEMBL203355 | 0.70 | — | — | |
| SCHEMBL28358159 | 0.70 | ALDH1A1 (0.48) | — | |
| SCHEMBL3401782 | 0.68 | GAA (0.46) | — | |
| SCHEMBL717594 | 0.68 | GAA (0.42) | — | |
| SCHEMBL11486594 | 0.67 | GAA (0.51) | — | |
| SCHEMBL28752228 | 0.67 | POLB (0.46) | — | |
| SCHEMBL28427136 | 0.67 | CYP3A4 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46424-E1 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2017-06-06 | — | — | US | claimed |
| US-8642761-B2 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2014-02-04 | — | — | US | claimed |
| US-20120065398-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | WILEX AG (DE) | 2012-03-15 | — | — | US | claimed |
| US-8088921-B2 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2012-01-03 | — | — | US | claimed |
| US-7884206-B2 | N-alpha-2,4,6-triisopropylphenylsulfonyl-3-cyano-(L)-phenylalanine-4-ethoxycarbonyl piperazide dissolved in ethanol, mixed with hydroxylamine hydrochloride to produce N- alpha -2,4,6-Triisopropylphenylsulfonyl-3-amidino-(L)-phenylalanine-4-ethoxycarbonyl piperazide hydrochloride, reduction with H2, Pd/C | WILEX AG (DE) | 2011-02-08 | — | — | US | claimed |
| US-7745441-B1 | triisopropylphenylsulfonyl N alpha -substituted 3-amidinophenylalanine derivatives, having increased inhibitory activity against urokinases, used as antitumor or antimetastatic agents | WILEX AG (DE) | 2010-06-29 | — | — | US | claimed |
| EP-1836197-A4 | SELECTIVE MUSCLE RELAXANT AND PHARMACEUTICAL COMPOSITIONS | UNIV FED (BR) | 2009-07-01 | — | — | EP | claimed |
| US-20080275105-A1 | Selective Muscle Relaxant and Pharmaceutical Compositions | UNIVERSIDADE FEDERAL DO RIO DE JANEIROUFRJ (BR) | 2008-11-06 | — | — | US | claimed |
| CN-100369906-C | Method for producing 3-amidinophenylalanine derivatives | PENTAPHARM AG (DE) | 2008-02-20 | — | — | CN | claimed |
| EP-1836197-A1 | SELECTIVE MUSCLE RELAXANT AND PHARMACEUTICAL COMPOSITIONS | Universidade Federal (BR) | 2007-09-26 | — | — | EP | claimed |
| US-20070123706-A1 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG | 2007-05-31 | — | — | US | claimed |
| EP-1480963-B1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | WILEX AG (DE) | 2007-05-02 | — | — | EP | claimed |
| WO-2006017921-A1 | SELECTIVE MUSCLE RELAXANT AND PHARMACEUTICAL COMPOSITIONS | UNIVERSIDADE FEDERAL DO RIO DE JANEIRO - UFRJ (BR) | 2006-02-23 | — | — | WO | claimed |
| US-20050176962-A1 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2005-08-11 | — | — | US | claimed |
| CN-1639142-A | Method for producing 3-amidinophenylalanine derivatives | PENTAPHARM AG (CH) | 2005-07-13 | — | — | CN | claimed |
| EP-1480963-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | Pentapharm AG (CH) | 2004-12-01 | — | — | EP | claimed |
| WO-2003072559-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | PENTAPHARM AG (CH) | 2003-09-04 | — | — | WO | claimed |
| EP-1114024-B1 | UROKINASE INHIBITORS | PENTAPHARM AG (CH) | 2002-11-27 | — | — | EP | claimed |
| EP-3095467-B1 | ANTIBODY-ENZYME CONJUGATE | VENTANA MED SYST INC (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-1114024-B1 | UROKINASE INHIBITORS | PENTAPHARM AG (CH) | 2002-11-27 | — | — | EP | disclosed |