⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4276631 | 0.79 | CES2 (0.50) | — | |
| SCHEMBL41570 | 0.79 | CES2 (0.50) | — | |
| SCHEMBL810985 | 0.76 | — | — | |
| SCHEMBL8845699 | 0.74 | CES2 (0.41) | — | |
| SCHEMBL2312133 | 0.73 | — | — | |
| SCHEMBL2044327 | 0.73 | — | — | |
| SCHEMBL7527333 | 0.73 | — | — | |
| SCHEMBL2651481 | 0.73 | — | — | |
| SCHEMBL1038340 | 0.73 | — | — | |
| SCHEMBL420435 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117860770-A | Application of 2-fluoroketolide compound in preparation of anti-coronavirus drugs | 中国医学科学院医药生物技术研究所 | 2024-04-12 | — | — | CN | claimed |
| EP-0850948-B1 | Propiophenone derivatives and process for preparing the same | TANABE SEIYAKU CO (JP) | 2002-04-24 | — | — | EP | claimed |
| US-6048842-A | ANTIDIABETIC AGENT | TANABE SEIYAKU CO., LTD. (JP) | 2000-04-11 | — | — | US | claimed |
| EP-0850948-A1 | Propiophenone derivatives and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1998-07-01 | — | — | EP | claimed |
| EP-0180188-B1 | A COMPOSITION FOR INCREASING THE ANTI-CANCER ACTIVITY OF AN ANTI-CANCER COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | claimed |
| US-4221787-A | Esteramide prodrugs of anti-inflammatory corticosteroids | INTERX RESEARCH CORPORATION (US) | 1980-09-09 | — | — | US | claimed |
| CN-114380874-B | Macrolide antibiotics, preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2024-06-21 | — | — | CN | disclosed |
| CN-117860770-A | Application of 2-fluoroketolide compound in preparation of anti-coronavirus drugs | 中国医学科学院医药生物技术研究所 | 2024-04-12 | — | — | CN | disclosed |
| EP-3737673-B1 | PROCESS FOR PREPARING HALICHONDRIN MACROLIDES AND ANALOGS THEREOF BY A PRINS REACTION, AND INTERMEDIATES OF THIS PROCESS | EISAI R&D MAN CO LTD (JP) | 2024-03-06 | — | — | EP | disclosed |
| US-20230151022-A1 | PRINS REACTION AND COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES AND ANALOGS THEREOF | EISAI R&D MANAGEMENT CO, LTD. (JP) | 2023-05-18 | — | — | US | disclosed |
| US-11643418-B2 | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of analogs of halichondrin B | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2023-05-09 | — | — | US | disclosed |
| US-11542269-B2 | Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2023-01-03 | — | — | US | disclosed |
| CN-109942560-B | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B | 卫材R&D管理有限公司 | 2022-06-17 | — | — | CN | disclosed |
| EP-0832898-A2 | Substituted amino acid derivatives | BAYER AG (DE) | 1998-04-01 | — | — | EP | disclosed |
| EP-0180188-B1 | A COMPOSITION FOR INCREASING THE ANTI-CANCER ACTIVITY OF AN ANTI-CANCER COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |
| US-4221787-A | Esteramide prodrugs of anti-inflammatory corticosteroids | INTERX RESEARCH CORPORATION (US) | 1980-09-09 | — | — | US | disclosed |
| US-4192868-A | ANTIINFLAMMATORY, ANALGESIC | CIBA-GEIGY CORPORATION (US) | 1980-03-11 | — | — | US | disclosed |
| US-4177344-A | FIBRINOLYTIC, ANTICOAGULANT | CIBA-GEIGY CORPORATION (US) | 1979-12-04 | — | — | US | disclosed |
| US-4049797-A | 1-PHENOXY-2-HYDROXY-3-AMINO-PROPANE-SUGAR COMPOUND | CIBA-GEIGY CORPORATION (US) | 1977-09-20 | — | — | US | disclosed |
| US-3978041-A | CARDIAC INSUFFICIENCY | CIBA-GEIGY CORPORATION (US) | 1976-08-31 | — | — | US | disclosed |