SCHEMBL20508307

SCHEMBL20508307

COc1ccc(B2OC(C)(C)C(C)(C)O2)c(F)c1F

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LPL P06858 4/20 0.40
LIPG Q9Y5X9 4/20 0.40
EGFR P00533 2/20 0.37
UCHL1 P09936 1/20 0.34
CSF1R P07333 1/20 0.33
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
TUBB1 Q9H4B7 1/20 0.31
P2RX7 Q99572 1/20 0.30
MRGPRX4 Q96LA9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30385846 1.00 LPL (0.40) LPLLIPGEGFRUCHL1CSF1R
SCHEMBL30129031 0.88 LPL (0.37) LPLLIPGEGFRCSF1RTUBB1
SCHEMBL23692939 0.88 LPL (0.37) LPLLIPGEGFRCSF1RTUBB1
SCHEMBL16046869 0.87 EGFR (0.39) LPLLIPGEGFRUCHL1CSF1R
SCHEMBL25209269 0.87 LPL (0.36) LPLLIPGEGFRCSF1RCA1
SCHEMBL23538053 0.87 EGFR (0.39) LPLLIPGEGFRUCHL1CSF1R
SCHEMBL30129234 0.87 EGFR (0.39) LPLLIPGEGFRUCHL1CSF1R
SCHEMBL29427091 0.86 LPL (0.41) LPLLIPGEGFRCSF1RCA1
SCHEMBL9948522 0.86 LPL (0.41) LPLLIPGEGFRCSF1RCA1
SCHEMBL21823670 0.85 FPR2 (0.38) LPLLIPGEGFRUCHL1TUBB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023118267-A1 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS GALECTO BIOTECH AB (DK) 2023-06-29 WO disclosed
WO-2023118267-A1 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS GALECTO BIOTECH AB (DK) 2023-06-29 WO disclosed
CN-115916784-A Novel imidazopyrazine derivatives 豪夫迈·罗氏有限公司 2023-04-04 CN disclosed
WO-2022256702-A1 SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-12-08 WO disclosed
EP-3255042-B1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME BEYONDBIO INC (KR) 2020-12-30 EP disclosed
US-20200190062-A1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME BEYONDBIO INC. (KR) 2020-06-18 US disclosed
US-10611754-B2 Heterocyclic compound and pharmaceutical composition comprising same BEYONDBIO INC. (KR) 2020-04-07 US disclosed
US-20190135786-A1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME BEYONDBIO INC. (KR) 2019-05-09 US disclosed
US-10227328-B2 Heterocyclic compound and pharmaceutical composition comprising same BEYONDBIO INC. (KR) 2019-03-12 US disclosed
US-20180273510-A1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME BEYONDBIO INC. (KR) 2018-09-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190135786-A1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME CDK5, CDK1, CDK4 LPL 3271/4885LIPG 3705/4885EGFR 875/4885
US-10227328-B2 Heterocyclic compound and pharmaceutical composition comprising same CDK5, CDK1, CDK4 LPL 3271/4885LIPG 3705/4885EGFR 875/4885
US-20200190062-A1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME CDK5, CDK3, CDK1 LPL 3421/4885LIPG 3326/4885EGFR 1057/4885
US-20180273510-A1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME CDK5, CDK1, CDK4 LPL 3271/4885LIPG 3705/4885EGFR 875/4885
US-10611754-B2 Heterocyclic compound and pharmaceutical composition comprising same CDK5, CDK1, CDK4 LPL 3271/4885LIPG 3705/4885EGFR 875/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.