SCHEMBL20509554

SCHEMBL20509554

Cc1cccc(C(=O)O)c1OCC(=O)O

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.60
KDM4E B2RXH2 3/20 0.60
HPGD P15428 2/20 0.60
HSD17B10 Q99714 2/20 0.60
KMT2A Q03164 5/20 0.51
CD69 Q07108 3/20 0.50
PTGDR2 Q9Y5Y4 1/20 0.49
MEN1 O00255 2/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
POLB P06746 1/20 0.46
MYC P01106 1/20 0.46
ALOX15 P16050 1/20 0.44
MAPK1 P28482 1/20 0.44
LMNA P02545 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL830740 0.87 KMT2A (0.60) ALDH1A1KDM4EHSD17B10KMT2ACD69
SCHEMBL20509584 0.87 KMT2A (0.60) ALDH1A1KDM4EHPGDHSD17B10KMT2A
SCHEMBL8024016 0.86 ALDH1A1 (0.64) ALDH1A1KDM4EHPGDHSD17B10KMT2A
SCHEMBL28456544 0.84 ALDH1A1 (0.62) ALDH1A1KDM4EHPGDHSD17B10KMT2A
SCHEMBL1989131 0.84 ALDH1A1 (0.62) ALDH1A1KDM4EHPGDHSD17B10KMT2A
SCHEMBL4146426 0.84 ALDH1A1 (0.54) ALDH1A1KDM4EHPGDHSD17B10KMT2A
SCHEMBL7695345 0.82 KDM4E (0.55) ALDH1A1KDM4EHPGDHSD17B10MYC
SCHEMBL13951454 0.81 ALDH1A1 (0.58) ALDH1A1KDM4EHPGDHSD17B10KMT2A
SCHEMBL29263206 0.81 PTPN1 (0.59) ALDH1A1KDM4EHPGDHSD17B10KMT2A
SCHEMBL383490 0.81 ALDH1A1 (0.58) ALDH1A1KDM4EHPGDHSD17B10KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3601216-B1 SUBSTITUTED DIHYDROINDENE-4-CARBOXAMIDES AND ANALOGS THEREOF, AND METHODS USING SAME FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION ARBUTUS BIOPHARMA CORP (CA) 2023-10-25 EP disclosed
EP-3601216-B1 SUBSTITUTED DIHYDROINDENE-4-CARBOXAMIDES AND ANALOGS THEREOF, AND METHODS USING SAME FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION ARBUTUS BIOPHARMA CORP (CA) 2023-10-25 EP disclosed
EP-3601216-A1 SUBSTITUTED DIHYDROINDENE-4-CARBOXAMIDES AND ANALOGS THEREOF, AND METHODS USING SAME Arbutus Biopharma Corporation (CA) 2020-02-05 EP disclosed
WO-2018172852-A1 SUBSTITUTED DIHYDROINDENE-4-CARBOXAMIDES AND ANALOGS THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2018-09-27 WO disclosed