Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382128 | 0.92 | KDM4E (0.57) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL28423414 | 0.90 | KMT2A (0.53) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL27676707 | 0.89 | PTPN11 (0.56) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL13951454 | 0.87 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL1989131 | 0.86 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL29057024 | 0.85 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL2216094 | 0.85 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL28602270 | 0.85 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL8024016 | 0.84 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL7695345 | 0.84 | KDM4E (0.55) | ALDH1A1KDM4EHPGDHSD17B10MYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101625-B2 | Pyrimidinones as Casein Kinase II (CK2) modulators | EXELIXIS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| EP-1948617-B1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS INC (US) | 2011-07-27 | — | — | EP | disclosed |