Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL101874 | 0.86 | JAK1 (0.33) | JAK1JAK2SIGMAR1TYK2JAK3 | |
| SCHEMBL22584056 | 0.73 | JAK2 (0.35) | JAK1JAK2SIGMAR1TYK2JAK3 | |
| SCHEMBL98626 | 0.72 | JAK2 (0.35) | JAK1JAK2SIGMAR1TYK2JAK3 | |
| SCHEMBL100209 | 0.71 | JAK2 (0.37) | JAK1JAK2TYK2JAK3HDAC6 | |
| SCHEMBL16673721 | 0.71 | JAK2 (0.58) | JAK1JAK2TYK2JAK3HDAC3 | |
| SCHEMBL99607 | 0.70 | JAK2 (0.40) | JAK1JAK2SIGMAR1TYK2JAK3 | |
| SCHEMBL100749 | 0.69 | TPH1 (0.35) | JAK1JAK2SIGMAR1TYK2JAK3 | |
| SCHEMBL99469 | 0.68 | JAK1 (0.33) | JAK1JAK2SIGMAR1TYK2JAK3 | |
| SCHEMBL101721 | 0.68 | JAK2 (0.41) | JAK1JAK2SIGMAR1TYK2JAK3 | |
| SCHEMBL16673537 | 0.68 | SIGMAR1 (0.34) | JAK1JAK2SIGMAR1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184526-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2018-10-03 | — | — | EP | disclosed |