Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20514983 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2HTTL3MBTL1ALDH1A1CYP2D6 | |
| SCHEMBL5966879 | 0.94 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTL3MBTL1ALDH1A1CYP2D6 | |
| SCHEMBL7440531 | 0.88 | REN (0.45) | SMN1; SMN2HTTL3MBTL1ALDH1A1PSMB1 | |
| SCHEMBL5967356 | 0.88 | SMN1; SMN2 (0.58) | SMN1; SMN2HTTL3MBTL1ALDH1A1CYP2D6 | |
| SCHEMBL20515051 | 0.88 | SMN1; SMN2 (0.58) | SMN1; SMN2HTTL3MBTL1ALDH1A1CYP2D6 | |
| SCHEMBL7361914 | 0.87 | HTT (0.43) | SMN1; SMN2HTTL3MBTL1PSMB1PSMB5 | |
| SCHEMBL20514968 | 0.86 | SMN1; SMN2 (0.60) | SMN1; SMN2HTTL3MBTL1ALDH1A1CYP2C9 | |
| SCHEMBL20514969 | 0.86 | SMN1; SMN2 (0.60) | SMN1; SMN2HTTL3MBTL1ALDH1A1CYP2C9 | |
| SCHEMBL11627381 | 0.83 | SMN1; SMN2 (0.62) | SMN1; SMN2HTTL3MBTL1ALDH1A1CYP2D6 | |
| SCHEMBL6136373 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2HTTL3MBTL1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3381898-A1 | SYMMETRICAL TRIS-ARYL-AMIDE DERIVATIVES AND THEIR USE AS ANTI-HEPARANASE | Leadiant Biosciences SA (CH) | 2018-10-03 | — | — | EP | disclosed |