Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | FRK | P42685 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18249536 | 0.83 | SLC6A2 (0.43) | CHEK2DHODHITGB3ITGA2BSLC6A2 | |
| SCHEMBL18257165 | 0.80 | ALDH1A1 (0.48) | CHEK2DHODHITGB3ITGA2B | |
| SCHEMBL14334507 | 0.79 | AURKA (0.46) | CHEK2PARP1IRAK4MKNK2ITGB3 | |
| SCHEMBL20515229 | 0.78 | PARP1 (0.52) | PARP1IRAK4MKNK2PIM1PLK4 | |
| SCHEMBL18257170 | 0.75 | TMEM97 (0.51) | PIM2 | |
| SCHEMBL18257171 | 0.75 | TMEM97 (0.59) | — | |
| SCHEMBL20515224 | 0.72 | PARP1 (0.58) | PARP1IRAK4MKNK2PIM1PLK4 | |
| SCHEMBL29923698 | 0.72 | PARP1 (0.58) | PARP1IRAK4MKNK2PIM1PLK4 | |
| Hydrochloric Acid SCHEMBL31753377 | 0.72 | CHEK2 (0.53) | CHEK2DHODHITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL31752567 | 0.72 | CHEK2 (0.53) | CHEK2DHODHITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10457662-B2 | Substituted amides for treating and preventing cancer | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-29 | — | — | US | disclosed |
| US-20180282296-A1 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CANCER | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2018-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180282296-A1 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CANCER | NNT, NQO1, NAMPT | CHEK2 799/4885DHODH 833/4885PARP1 70/4885 |
| US-10457662-B2 | Substituted amides for treating and preventing cancer | NQO1, NNT, SIRT1 | CHEK2 1544/4885DHODH 726/4885PARP1 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.