Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | HNF4A | P41235 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2716993 | 0.85 | L3MBTL1 (0.52) | L3MBTL1MRGPRX4RXRAALDH1A1POLB | |
| SCHEMBL2715678 | 0.85 | L3MBTL1 (0.52) | L3MBTL1MRGPRX4RXRAALDH1A1POLB | |
| SCHEMBL2715270 | 0.83 | L3MBTL1 (0.51) | L3MBTL1MRGPRX4RXRAALDH1A1POLB | |
| SCHEMBL2715284 | 0.79 | L3MBTL1 (0.47) | L3MBTL1MRGPRX4RXRAALDH1A1POLB | |
| SCHEMBL2716927 | 0.79 | L3MBTL1 (0.55) | L3MBTL1MRGPRX4RXRAALDH1A1POLB | |
| SCHEMBL2716074 | 0.79 | L3MBTL1 (0.55) | L3MBTL1MRGPRX4RXRAALDH1A1POLB | |
| SCHEMBL14762361 | 0.77 | L3MBTL1 (0.54) | L3MBTL1MRGPRX4RXRAALDH1A1POLB | |
| SCHEMBL2715676 | 0.77 | L3MBTL1 (0.54) | L3MBTL1MRGPRX4RXRAALDH1A1POLB | |
| SCHEMBL439221 | 0.77 | L3MBTL1 (0.54) | L3MBTL1MRGPRX4RXRAALDH1A1POLB | |
| SCHEMBL2714025 | 0.77 | L3MBTL1 (0.54) | L3MBTL1MRGPRX4RXRAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180280352-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | HOFFMANN-LA ROCHE INC. (US) | 2018-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180280352-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | NPY1R, NPY2R, DECR1 | L3MBTL1 2060/4885MRGPRX4 760/4885RXRA 1597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.