Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Amikacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.98 |
| ▸ | RAD52 | P43351 | 1/20 | 0.98 |
| ▸ | GJB2 | P29033 | 2/20 | 0.66 |
| ▸ | GJA1 | P17302 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amikacin SCHEMBL2637141 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL15263372 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL15171896 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL23308753 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL20522644 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL24437395 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL15263403 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL15515830 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL20516498 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL13260939 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210128594-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISORDERS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2021-05-06 | — | — | US | disclosed |
| US-10668092-B2 | Compositions and methods for treatment of inflammatory disorders | THE JOHN HOPKINS UNIVERSITY (US) | 2020-06-02 | — | — | US | disclosed |
| US-20180280418-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISORDERS | THE JOHNS HOPKINS UNIVERSITY | 2018-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180280418-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISORDERS | TLR4, TLR3, TLR2 | LMNA 2016/4885ALOX15 170/4885RAD52 4771/4885 |
| US-10668092-B2 | Compositions and methods for treatment of inflammatory disorders | TLR4, TLR3, TLR2 | LMNA 2016/4885ALOX15 170/4885RAD52 4771/4885 |
| US-20210128594-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISORDERS | TLR4, TLR3, TLR2 | LMNA 2016/4885ALOX15 170/4885RAD52 4771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.