Amikacin

SCHEMBL20522644

NCCC(O)C(=O)NC1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Amikacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	LMNA	P02545	3/20	1.00

▸	ALOX15	P16050	3/20	0.98

▸	RAD52	P43351	1/20	0.98

▸	GJB2	P29033	2/20	0.66

▸	GJA1	P17302	1/20	0.66

▸	MEN1	O00255	1/20	0.66

▸	CYP2C9	P11712	1/20	0.66

▸	TSHR	P16473	1/20	0.66

▸	KMT2A	Q03164	1/20	0.66

▸	ALDH1A1	P00352	1/20	0.66

▸	MAPT	P10636	1/20	0.63

▸	KDM4E	B2RXH2	1/20	0.59

▸	HPSE	Q9Y251	1/20	0.53

▸	CYP3A4	P08684	1/20	0.53

▸	GAA	P10253	1/20	0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Amikacin SCHEMBL2637141	1.00	LMNA (1.00)	LMNAALOX15RAD52GJB2GJA1
Amikacin SCHEMBL20516499	1.00	LMNA (1.00)	LMNAALOX15RAD52GJB2GJA1
Amikacin SCHEMBL15263372	1.00	LMNA (1.00)	LMNAALOX15RAD52GJB2GJA1
Amikacin SCHEMBL15171896	1.00	LMNA (1.00)	LMNAALOX15RAD52GJB2GJA1
Amikacin SCHEMBL23308753	1.00	LMNA (1.00)	LMNAALOX15RAD52GJB2GJA1
Amikacin SCHEMBL24437395	1.00	LMNA (1.00)	LMNAALOX15RAD52GJB2GJA1
Amikacin SCHEMBL15263403	1.00	LMNA (1.00)	LMNAALOX15RAD52GJB2GJA1
Amikacin SCHEMBL15515830	1.00	LMNA (1.00)	LMNAALOX15RAD52GJB2GJA1
Amikacin SCHEMBL20516498	1.00	LMNA (1.00)	LMNAALOX15RAD52GJB2GJA1
Amikacin SCHEMBL13260939	1.00	LMNA (1.00)	LMNAALOX15RAD52GJB2GJA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2018182515-A1	METHODS OF MODIFYING FUNGI AND USES THEREOF	AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG)	2018-10-04	—	—	WO	disclosed