Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 14/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 14/20 | 0.56 |
| ▸ | ACVR1 | Q04771 | 12/20 | 0.56 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21630350 | 0.90 | NOD2 (0.61) | NOD2RIPK2ACVR1NOD1TGFBR1 | |
| SCHEMBL21630369 | 0.86 | NOD2 (0.68) | NOD2RIPK2ACVR1NOD1TGFBR1 | |
| SCHEMBL21630433 | 0.86 | NOD2 (0.65) | NOD2RIPK2ACVR1NOD1TGFBR1 | |
| SCHEMBL21630382 | 0.80 | NOD2 (0.63) | NOD2RIPK2ACVR1TGFBR1 | |
| SCHEMBL20523635 | 0.79 | NOD2 (1.00) | NOD2RIPK2ACVR1NOD1TGFBR1 | |
| SCHEMBL21630356 | 0.76 | LMNA (0.51) | NOD2RIPK2ACVR1 | |
| SCHEMBL20523500 | 0.76 | ACVR1 (0.62) | NOD2RIPK2ACVR1TGFBR1FYN | |
| SCHEMBL21630387 | 0.76 | ACVR1 (0.51) | NOD2RIPK2ACVR1TGFBR1FYN | |
| SCHEMBL21630442 | 0.76 | NOD2 (0.54) | NOD2RIPK2ACVR1TGFBR1FYN | |
| SCHEMBL20523650 | 0.74 | KMT2A (0.47) | ACVR1TGFBR1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600307-A1 | COMPOSITIONS FOR USE IN METHODS OF INHIBITING PROTEIN KINASES | University of Houston System (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183633-A1 | COMPOSITIONS FOR USE IN METHODS OF INHIBITING PROTEIN KINASES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2018-10-04 | — | — | WO | disclosed |