Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16756490 | 0.84 | L3MBTL1 (0.34) | LMNACCNCCDK8SMN1; SMN2L3MBTL1 | |
| SCHEMBL782704 | 0.79 | RPS6KA3 (0.37) | LMNACCNCCDK8SMN1; SMN2RPS6KA3 | |
| SCHEMBL23639284 | 0.78 | CYP2D6 (0.42) | LMNAPDE2ARPS6KA3CYP3A4GAA | |
| SCHEMBL13385945 | 0.78 | PDE2A (0.47) | LMNAPDE2ASMN1; SMN2L3MBTL1RPS6KA3 | |
| SCHEMBL8263256 | 0.74 | LMNA (0.35) | LMNAPDE2ACYP3A4BLMGAA | |
| SCHEMBL9846960 | 0.74 | GAA (0.39) | LMNAPDE2AL3MBTL1KMT2AMAPT | |
| SCHEMBL31250363 | 0.74 | RPS6KA3 (0.42) | LMNACCNCCDK8CA12CA1 | |
| SCHEMBL3810939 | 0.74 | RPS6KA3 (0.42) | LMNACCNCCDK8CA12CA1 | |
| SCHEMBL27491538 | 0.74 | HTT (0.37) | LMNACCNCCDK8KMT2ACYP3A4 | |
| SCHEMBL1770142 | 0.73 | CA12 (0.38) | CA12CA1CA2CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601284-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | H. Hoffnabb-La Roche Ag (CH) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183956-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2018-10-04 | — | — | WO | disclosed |