Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16416156 | 0.78 | — | — | |
| SCHEMBL26122897 | 0.65 | HTR2A (0.33) | HTR2AHTR2CCHRNA4 | |
| SCHEMBL27144340 | 0.65 | KDM4E (0.35) | — | |
| SCHEMBL12027329 | 0.64 | OPRM1 (0.42) | HTR2AHTR2CCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL21001854 | 0.63 | MAPK8 (0.30) | — | |
| SCHEMBL3469250 | 0.63 | MAPK8 (0.30) | — | |
| Hydrochloric Acid SCHEMBL2595722 | 0.63 | OPRM1 (0.41) | HTR2AHTR2CCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL21193357 | 0.62 | HTR2A (0.40) | HTR2AHTR2C | |
| SCHEMBL7703222 | 0.62 | ABL1 (0.34) | HTR2AHTR2CCHRNB2CHRNA4CHRNB4 | |
| Hydrochloric Acid SCHEMBL2596286 | 0.61 | ABL1 (0.33) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601284-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | H. Hoffnabb-La Roche Ag (CH) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183956-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2018-10-04 | — | — | WO | disclosed |