Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.30 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.30 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.30 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.30 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.30 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.30 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21001854 | 1.00 | MAPK8 (0.30) | MAPK8MAPK9MAPK10KCNH2HRH3 | |
| SCHEMBL26130701 | 0.81 | PRKAB2 (0.35) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL27248736 | 0.80 | GHSR (0.31) | KCNH2HRH3 | |
| SCHEMBL17713790 | 0.80 | PRKAG1 (0.31) | KCNH2HRH3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL25293416 | 0.78 | PLK1 (0.31) | — | |
| SCHEMBL21465720 | 0.76 | — | — | |
| SCHEMBL28881758 | 0.76 | ALDH1A1 (0.31) | — | |
| SCHEMBL20077896 | 0.74 | PDE5A (0.34) | — | |
| SCHEMBL29218326 | 0.74 | IRAK4 (0.35) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL21465726 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814357-A1 | HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2021-05-05 | — | — | EP | disclosed |
| EP-2215085-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009053737-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | WO | disclosed |