Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31210513 | 0.89 | SLC6A4 (0.42) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL31210650 | 0.89 | SLC6A4 (0.42) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL21043411 | 0.86 | KMT2A (0.34) | PYGLNFKB1NFKB2RELACA14 | |
| SCHEMBL4660108 | 0.85 | SLC6A4 (0.42) | PYGLSLC6A2SLC6A4RENSLC6A3 | |
| SCHEMBL2822608 | 0.84 | HDAC6 (0.33) | NFKB1NFKB2RELACA14HDAC6 | |
| SCHEMBL3813845 | 0.81 | NFKB1 (0.38) | NFKB1NFKB2RELACA14HDAC6 | |
| SCHEMBL23578633 | 0.79 | NFKB1 (0.31) | NFKB1NFKB2RELACA14HDAC6 | |
| SCHEMBL21298613 | 0.79 | SMYD3 (0.33) | — | |
| SCHEMBL13207042 | 0.79 | PIK3CD (0.40) | — | |
| SCHEMBL12827200 | 0.78 | L3MBTL1 (0.33) | PYGLNFKB1NFKB2RELACA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |
| EP-3601284-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | H. Hoffnabb-La Roche Ag (CH) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183956-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2018-10-04 | — | — | WO | disclosed |