Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.31 |
| ▸ | CA1 | P00915 | 3/20 | 0.31 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
| ▸ | CA9 | Q16790 | 3/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635447 | 0.75 | KDM4C (0.43) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL31065932 | 0.74 | KDM4C (0.44) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL28796337 | 0.74 | NPC1 (0.50) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL29749639 | 0.74 | NPC1 (0.50) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL24669516 | 0.73 | KDM4C (0.51) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL772902 | 0.72 | KDM4C (0.53) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL30049433 | 0.72 | KDM4C (0.50) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL2633488 | 0.72 | KDM4C (0.56) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL29447734 | 0.72 | KDM4C (0.53) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL4078714 | 0.71 | KDM4C (0.49) | KDM4CL3MBTL1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601284-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | H. Hoffnabb-La Roche Ag (CH) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183956-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2018-10-04 | — | — | WO | disclosed |