Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27539766 | 0.83 | ATM (0.57) | MAPTGAAHPGDHTTSMN1; SMN2 | |
| SCHEMBL30433192 | 0.83 | ATM (0.57) | MAPTGAAHPGDHTTSMN1; SMN2 | |
| SCHEMBL11722198 | 0.81 | ALDH1A1 (0.56) | MAPTGAAHPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL29960870 | 0.80 | NPC1 (0.61) | MAPTGAAHPGDCRHBPCRHR2 | |
| SCHEMBL29083934 | 0.80 | NPC1 (0.61) | MAPTGAAHPGDCRHBPCRHR2 | |
| SCHEMBL1607866 | 0.79 | TP53 (0.55) | MAPTGAAHPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL940807 | 0.79 | TP53 (0.55) | MAPTGAAHPGDSMN1; SMN2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11722776 | 0.77 | TP53 (0.53) | MAPTGAAHPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL287220 | 0.77 | ALDH1A1 (0.56) | MAPTGAAHPGDSMN1; SMN2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11722772 | 0.77 | TP53 (0.53) | MAPTGAAHPGDSMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600312-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183145-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-10-04 | — | — | WO | disclosed |