Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2051000 | 0.86 | PIK3CD (0.33) | TMIGD3ADORA2AADORA1ADORA2B | |
| SCHEMBL2164179 | 0.82 | PIK3CD (0.41) | — | |
| SCHEMBL2038100 | 0.79 | PIK3CD (0.41) | ADORA2AADORA1ADORA2B | |
| Trifluoroacetic Acid SCHEMBL2052496 | 0.79 | PIK3CD (0.35) | — | |
| SCHEMBL2165865 | 0.70 | PIK3CD (0.47) | — | |
| SCHEMBL9960866 | 0.70 | LMNA (0.36) | ALDH1A1 | |
| SCHEMBL2016719 | 0.68 | PIK3CD (0.47) | — | |
| SCHEMBL2017997 | 0.67 | PIK3CD (0.39) | — | |
| SCHEMBL2012486 | 0.67 | PIK3CD (0.46) | — | |
| Trifluoroacetic Acid SCHEMBL2050998 | 0.65 | PIK3CD (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |