Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.58 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.58 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.58 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525383 | 0.88 | MAPT (0.60) | TP53PABPC1APOBEC3AEIF4HAPOBEC3G | |
| SCHEMBL16431347 | 0.87 | DRD2 (0.68) | TP53MEN1KMT2APABPC1APOBEC3A | |
| SCHEMBL16432486 | 0.81 | TP53 (0.74) | TP53MEN1KMT2APABPC1APOBEC3A | |
| SCHEMBL17837146 | 0.80 | DRD2 (0.50) | MAPTDRD2POLB | |
| SCHEMBL16432683 | 0.80 | DRD2 (0.70) | TP53MEN1KMT2APABPC1APOBEC3A | |
| SCHEMBL20525397 | 0.80 | DRD2 (0.70) | TP53MEN1KMT2APABPC1APOBEC3A | |
| SCHEMBL16432463 | 0.79 | DRD2 (0.70) | TP53MEN1KMT2APABPC1APOBEC3A | |
| SCHEMBL16432620 | 0.79 | DRD2 (0.82) | TP53MEN1KMT2APABPC1APOBEC3A | |
| SCHEMBL16430832 | 0.77 | DRD2 (0.65) | TP53MEN1KMT2APABPC1APOBEC3A | |
| SCHEMBL20525396 | 0.77 | DRD2 (0.76) | TP53MEN1KMT2APABPC1APOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027612-B1 | 11-OXO-10,11-DIHYDRODIBENZO[B,F][1,4]THIAZEPINE S-OXIDE DERIVATIVES AND THEIR USE AS DOPAMINE D2 RECEPTOR ANTAGONISTS | US HEALTH (US) | 2018-10-10 | — | — | EP | claimed |