Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.70 |
| ▸ | DRD3 | P35462 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.58 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.58 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.58 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16432683 | 1.00 | DRD2 (0.70) | DRD2DRD3MEN1KMT2ATP53 | |
| SCHEMBL16431347 | 0.92 | DRD2 (0.68) | DRD2DRD3MEN1KMT2ATP53 | |
| SCHEMBL16432463 | 0.88 | DRD2 (0.70) | DRD2DRD3MEN1KMT2ATP53 | |
| SCHEMBL17837182 | 0.80 | DRD2 (0.68) | DRD2DRD3LMNAMAPTSMN1; SMN2 | |
| SCHEMBL20525393 | 0.80 | DRD2 (0.68) | DRD2DRD3LMNAMAPTSMN1; SMN2 | |
| SCHEMBL17837125 | 0.80 | DRD2 (0.68) | DRD2DRD3LMNAMAPTSMN1; SMN2 | |
| SCHEMBL17837126 | 0.80 | DRD2 (0.68) | DRD2DRD3LMNAMAPTSMN1; SMN2 | |
| SCHEMBL17837195 | 0.80 | DRD2 (0.68) | DRD2DRD3LMNAMAPTSMN1; SMN2 | |
| SCHEMBL20525446 | 0.80 | TP53 (0.59) | DRD2MEN1KMT2ATP53PABPC1 | |
| SCHEMBL20525375 | 0.79 | LMNA (0.67) | DRD2TP53PABPC1APOBEC3AEIF4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027612-B1 | 11-OXO-10,11-DIHYDRODIBENZO[B,F][1,4]THIAZEPINE S-OXIDE DERIVATIVES AND THEIR USE AS DOPAMINE D2 RECEPTOR ANTAGONISTS | US HEALTH (US) | 2018-10-10 | — | — | EP | claimed |