SCHEMBL20525546

SCHEMBL20525546

NC(=O)c1ccc(Cn2ccc3cc(C4CCN(Cc5noc(C(F)(F)F)n5)CC4)cnc32)cc1O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 10/20 0.36
EGLN1 Q9GZT9 2/20 0.35
HTT P42858 1/20 0.34
HDAC1 Q13547 6/20 0.34
HDAC8 Q9BY41 4/20 0.34
HDAC4 P56524 5/20 0.33
HDAC3 O15379 2/20 0.33
HDAC7 Q8WUI4 2/20 0.33
HDAC9 Q9UKV0 2/20 0.33
HDAC5 Q9UQL6 2/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33
HTR1A P08908 1/20 0.32
DRD2 P14416 1/20 0.32
HTR2A P28223 1/20 0.32
NCOR2 Q9Y618 1/20 0.32
MAPK1 P28482 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PIK3CA P42336 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20525469 0.87 PIK3CA (0.42) EGLN1PIK3CAPRKAA2
SCHEMBL20525424 0.85 EGLN1 (0.38) EGLN1CNR1CNR2
SCHEMBL20525405 0.84 PARP1 (0.45) HTT
SCHEMBL16804308 0.84 HDAC4 (0.42) HDAC6EGLN1HDAC1HDAC8HDAC4
SCHEMBL20525454 0.83 SYK (0.42) EGLN1HDAC1HDAC3HDAC2
SCHEMBL18108972 0.83 HDAC4 (0.39) HDAC6HTTHDAC4HDAC3HDAC7
SCHEMBL20525358 0.83 EGLN1 (0.42) EGLN1CNR1CNR2
SCHEMBL20525317 0.82 EGLN1 (0.39) EGLN1CNR1CNR2
SCHEMBL20525400 0.81 PARP1 (0.41) EGLN1CNR1CNR2
SCHEMBL20525322 0.81 EGLN1 (0.35) EGLN1CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3080125-B1 NOVEL AZAINDOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE (HDAC) INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME CHONG KUN DANG PHARMACEUTICAL CORP (KR) 2018-10-10 EP disclosed