Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 13/20 | 0.66 |
| ▸ | KDR | P35968 | 9/20 | 0.66 |
| ▸ | MET | P08581 | 5/20 | 0.64 |
| ▸ | KIT | P10721 | 3/20 | 0.62 |
| ▸ | AXL | P30530 | 1/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371902 | 0.92 | PDGFRA (0.67) | PDGFRAKDRMETKITAXL | |
| SCHEMBL371901 | 0.92 | PDGFRA (0.67) | PDGFRAKDRMETKITAXL | |
| SCHEMBL6690550 | 0.86 | MET (0.68) | PDGFRAKDRMETKITAXL | |
| SCHEMBL372068 | 0.86 | PDGFRA (0.68) | PDGFRAKDRMETKITAXL | |
| SCHEMBL372067 | 0.86 | PDGFRA (0.68) | PDGFRAKDRMETKITAXL | |
| SCHEMBL13210880 | 0.86 | PDGFRA (0.68) | PDGFRAKDRMETKITAXL | |
| SCHEMBL372059 | 0.84 | PDGFRA (0.64) | PDGFRAKDRMETKITAXL | |
| SCHEMBL20525576 | 0.84 | MET (0.46) | PDGFRAKDRMETKITAXL | |
| SCHEMBL29693604 | 0.84 | PDGFRA (0.64) | PDGFRAKDRMETKITAXL | |
| SCHEMBL371835 | 0.84 | PDGFRA (0.66) | PDGFRAKDRMETKITAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |