Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 6/20 | 0.39 |
| ▸ | IGF1R | P08069 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525681 | 0.94 | MET (0.47) | METFLT3KDRIGF1R | |
| SCHEMBL20525690 | 0.94 | MET (0.48) | METFLT3KDRIGF1RALDH1A1 | |
| SCHEMBL20525701 | 0.94 | MET (0.49) | METFLT3KDRIGF1R | |
| SCHEMBL20525683 | 0.93 | MET (0.48) | METFLT3KDR | |
| SCHEMBL20525667 | 0.93 | MET (0.53) | METFLT3KDRIGF1R | |
| SCHEMBL20525691 | 0.93 | MET (0.47) | METFLT3KDR | |
| SCHEMBL20525650 | 0.93 | MET (0.49) | METFLT3SMN1; SMN2KDRIGF1R | |
| SCHEMBL20525802 | 0.92 | MET (0.46) | METFLT3LMNASMN1; SMN2KDR | |
| SCHEMBL20525751 | 0.91 | MET (0.47) | METFLT3KDR | |
| SCHEMBL20525653 | 0.90 | MET (0.48) | METFLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |