Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525758 | 0.91 | HTT (0.49) | SMN1; SMN2HTTLMNAMAPTMEN1 | |
| SCHEMBL20525766 | 0.89 | ALDH1A1 (0.49) | SMN1; SMN2MEN1KMT2ABRAFALDH1A1 | |
| SCHEMBL20525750 | 0.89 | KDR (0.47) | LMNAMAPTMEN1KMT2AKDR | |
| SCHEMBL20525528 | 0.88 | AXL (0.46) | SMN1; SMN2MEN1KMT2AKDM4ENPSR1 | |
| SCHEMBL29693652 | 0.86 | KDR (0.59) | BRAFKDRMAPK14TNNI3KEGFR | |
| SCHEMBL378510 | 0.86 | KDR (0.59) | BRAFKDRMAPK14TNNI3KEGFR | |
| SCHEMBL20525674 | 0.86 | AXL (0.53) | SMN1; SMN2MAPTKMT2AL3MBTL1KDR | |
| SCHEMBL20525771 | 0.82 | KDR (0.53) | NPSR1ALDH1A1KDR | |
| SCHEMBL20525555 | 0.79 | AXL (0.52) | KMT2AKDREGFR | |
| SCHEMBL20525705 | 0.79 | AXL (0.45) | SMN1; SMN2KMT2AALDH1A1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |