Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | MERTK | Q12866 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525750 | 0.92 | KDR (0.47) | AXLMERTKKDRPDGFRAUSP2 | |
| SCHEMBL20525674 | 0.92 | AXL (0.53) | AXLMERTKPDE4DKDRPDGFRA | |
| SCHEMBL20525766 | 0.90 | ALDH1A1 (0.49) | AXLMERTKKDRPDGFRANOTUM | |
| SCHEMBL20525844 | 0.88 | SMN1; SMN2 (0.49) | KDRALDH1A1HPGDNPC1MEN1 | |
| SCHEMBL20525771 | 0.86 | KDR (0.53) | AXLMERTKKDRPDGFRAALDH1A1 | |
| SCHEMBL20525686 | 0.85 | MET (0.58) | AXLRORCKDRPDGFRAALDH1A1 | |
| SCHEMBL20525801 | 0.84 | POLB (0.52) | AXLMERTKPDE4DALDH1A1MET | |
| SCHEMBL371958 | 0.84 | PDGFRA (0.61) | AXLMERTKKDRPDGFRAMET | |
| SCHEMBL20525705 | 0.83 | AXL (0.45) | AXLMERTKKDRPDGFRAALDH1A1 | |
| SCHEMBL20525870 | 0.83 | AXL (0.42) | AXLMERTKRORCKDRPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |