Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2054239 | 0.92 | HTT (0.44) | HTTHDAC6MEN1KMT2APPARG | |
| Iodide SCHEMBL2051757 | 0.91 | HTT (0.43) | HTTHDAC6MEN1KMT2APPARG | |
| SCHEMBL2019895 | 0.88 | HTT (0.44) | HTTHDAC6MEN1KMT2AHDAC1 | |
| Iodide SCHEMBL2019374 | 0.87 | HTT (0.43) | HTTHDAC6MEN1KMT2AHDAC1 | |
| SCHEMBL2016153 | 0.80 | HTT (0.44) | HTTHDAC6MEN1KMT2APPARG | |
| Iodide SCHEMBL2019625 | 0.80 | HTT (0.43) | HTTHDAC6MEN1KMT2APPARG | |
| SCHEMBL2051754 | 0.79 | MEN1 (0.64) | HTTMEN1KMT2ATP53LMNA | |
| SCHEMBL2053732 | 0.77 | LMNA (0.64) | HTTMEN1KMT2ATP53LMNA | |
| SCHEMBL2052007 | 0.76 | MAPT (0.57) | HTTMEN1KMT2ATP53LMNA | |
| SCHEMBL2019532 | 0.76 | HDAC6 (0.49) | HTTHDAC6MEN1KMT2APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |