Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | THRB | P10828 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | RECQL | P46063 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | FGB | P02675 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | YWHAG | P61981 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017836 | 0.92 | HTT (0.46) | HDAC6KMT2ATHRBMEN1RECQL | |
| SCHEMBL2018490 | 0.91 | KDM4E (0.53) | HDAC6KMT2ATHRBMEN1RECQL | |
| SCHEMBL2014471 | 0.89 | MAPT (0.52) | HDAC6KMT2AMEN1RECQLALDH1A1 | |
| SCHEMBL17937045 | 0.87 | HDAC6 (0.43) | HDAC6KMT2ATHRBMEN1RECQL | |
| SCHEMBL2019895 | 0.87 | HTT (0.44) | HDAC6KMT2AMEN1HTTHSD17B10 | |
| Iodide SCHEMBL2019374 | 0.86 | HTT (0.43) | HDAC6KMT2AMEN1HTTHSD17B10 | |
| SCHEMBL2015349 | 0.85 | HTT (0.57) | KMT2AMEN1POLBHTTGAA | |
| SCHEMBL2016173 | 0.85 | HTT (0.42) | HDAC6RECQLALDH1A1HTTKDM4E | |
| SCHEMBL2020396 | 0.84 | HTT (0.48) | HDAC6KMT2AMEN1HTT | |
| SCHEMBL12635756 | 0.84 | HTT (0.49) | HDAC6KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |