SCHEMBL205280

SCHEMBL205280

O=C(CBr)c1ccc(C(=O)CBr)cc1

nearest known ligand 0.80

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 15/20 0.80
PTPN1 P18031 6/20 0.80
HDAC3 O15379 1/20 0.46
HDAC4 P56524 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC2 Q92769 1/20 0.46
HDAC10 Q969S8 1/20 0.46
HDAC11 Q96DB2 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
HDAC9 Q9UKV0 1/20 0.46
HDAC5 Q9UQL6 1/20 0.46
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28594745 0.92 GSK3B (0.70) GSK3BPTPN1
SCHEMBL689331 0.92 GSK3B (0.83) GSK3BPTPN1RAB9A
SCHEMBL79354 0.89 PTPN1 (1.00) GSK3BPTPN1NPC1RAB9A
SCHEMBL247615 0.89 GSK3B (0.70) GSK3BPTPN1
SCHEMBL9909658 0.89 GSK3B (0.67) GSK3BPTPN1HDAC3HDAC4HDAC1
SCHEMBL70930 0.89 GSK3B (1.00) GSK3BPTPN1HDAC3HDAC4HDAC1
SCHEMBL191879 0.87 GSK3B (0.64) GSK3BPTPN1
SCHEMBL6816324 0.87 GSK3B (0.64) GSK3BPTPN1
SCHEMBL10327311 0.87 PTPN1 (1.00) GSK3BPTPN1NPC1RAB9A
SCHEMBL5804589 0.87 PTPN1 (0.95) GSK3BPTPN1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0620500-A2 Resist and pattern formation using the same HITACHI, LTD. (JP) 1994-10-19 EP claimed
US-4052542-A HALO-ACETYL HIGH GREEN STRENGTH RUBBERS POLYSAR LIMITED (CA) 1977-10-04 US claimed
CN-113801005-B Preparation method of alpha-bromoacetophenone compound 浙江师范大学 2023-06-13 CN disclosed
CN-106588890-B Antiviral compounds 吉利德制药有限责任公司 2020-11-27 CN disclosed
EP-3626716-A1 ANTIVIRAL COMPOUNDS Gilead Pharmasset LLC (US) 2020-03-25 EP disclosed
US-9981955-B2 Antiviral compounds GILEAD PHARMASSET LLC (US) 2018-05-29 US disclosed
EP-3309157-A1 ANTIVIRAL COMPOUNDS Gilead Pharmasset LLC (US) 2018-04-18 EP disclosed
EP-3309157-A1 ANTIVIRAL COMPOUNDS Gilead Pharmasset LLC (US) 2018-04-18 EP disclosed
EP-3002281-B1 ANTIVIRAL COMPOUNDS GILEAD PHARMASSET LLC (US) 2017-09-13 EP disclosed
EP-3002281-B1 ANTIVIRAL COMPOUNDS GILEAD PHARMASSET LLC (US) 2017-09-13 EP disclosed
US-20170029408-A1 ANTIVIRAL COMPOUNDS GILEAD SCIENCES, INC. 2017-02-02 US disclosed
EP-2107054-A1 Antiproliferative compounds and therapeutic uses thereof Università Degli Studi Di Milano - Bicocca (IT) 2009-10-07 EP disclosed
EP-1410448-A1 NOVEL PHOTOSTRUCTURABLE ORGANIC SEMICONDUCTOR MATERIALS SIEMENS AKTIENGESELLSCHAFT (DE) 2004-04-21 EP disclosed
EP-0911153-B1 Image forming method KONISHIROKU PHOTO IND (JP) 2003-12-10 EP disclosed
WO-2002021611-A1 NOVEL PHOTOSTRUCTURABLE ORGANIC SEMICONDUCTOR MATERIALS SIEMENS AKTIENGESELLSCHAFT (DE) 2002-03-14 WO disclosed
US-6174646-B1 IMAGEWISE HEATING OR EXPOSING IMAGE FORMING MATERIAL TO LASER WHEREIN IMAGE FORMING MATERIAL COMPRISES SUPPORT HAVING RADIATION SENSITIVE LAYER CONTAINING DYE, AN ACID GENERATING COMPOUND CAPABLE OF GENERATING ACID ON IRRADIATION KONICA CORPORATION (JP) 2001-01-16 US disclosed
EP-0911153-A1 Image forming method KONICA CORPORATION (JP) 1999-04-28 EP disclosed
EP-0620500-A2 Resist and pattern formation using the same HITACHI, LTD. (JP) 1994-10-19 EP disclosed
US-4505842-A DOPED POLYOXAZOLES, -THIAZOLES AND -IMIDAZOLES; COATINGS; CASTINGS; WORKABILITY CHEVRON RESEARCH COMPANY (US) 1985-03-19 US disclosed
US-4249013-A Conjugatively linked tetrathiafulvalenes and method for preparation thereof BELL TELEPHONE LABORATORIES, INCORPORATED (US) 1981-02-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170029408-A1 ANTIVIRAL COMPOUNDS MAVS, EIF2AK2, ZC3HAV1 GSK3B 2041/4885PTPN1 4248/4885HDAC3 919/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.