Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALML3 | P27482 | 6/20 | 0.74 |
| ▸ | MAOA | P21397 | 8/20 | 0.61 |
| ▸ | MAOB | P27338 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29432578 | 1.00 | CALML3 (0.74) | CALML3MAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL18770294 | 1.00 | CALML3 (0.74) | CALML3MAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL18770257 | 0.90 | CALML3 (0.60) | CALML3MAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL18770254 | 0.90 | CALML3 (0.60) | CALML3MAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL22245214 | 0.90 | CALML3 (0.73) | CALML3MAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL29432583 | 0.90 | CALML3 (0.73) | CALML3MAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL23060435 | 0.89 | CALML3 (0.59) | CALML3MAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL21259487 | 0.89 | CALML3 (0.58) | CALML3MAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL18790170 | 0.89 | CALML3 (0.58) | CALML3MAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL20528026 | 0.87 | MAOA (0.57) | CALML3MAOAMAOBCYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10947205-B2 | Oxazolidinone compounds and methods of use thereof as antibacterial agents | MERCK SHARP & DOHME CORP. (US) | 2021-03-16 | — | — | US | disclosed |
| US-20210061777-A1 | OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2021-03-04 | — | — | US | disclosed |
| US-20190248753-A1 | OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME LLC | 2019-08-15 | — | — | US | disclosed |
| US-20180290987-A1 | OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME CORP. | 2018-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10947205-B2 | Oxazolidinone compounds and methods of use thereof as antibacterial agents | OXA1L, ERAL1, TBCD | CALML3 3904/4885MAOA 1773/4885MAOB 951/4885 |
| US-20190248753-A1 | OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS | OXA1L, ERAL1, TBCD | CALML3 3904/4885MAOA 1773/4885MAOB 951/4885 |
| US-20180290987-A1 | OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS | OXA1L, ERAL1, TBCD | CALML3 3904/4885MAOA 1773/4885MAOB 951/4885 |
| US-20210061777-A1 | OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS | OXA1L, ERAL1, TBCD | CALML3 3904/4885MAOA 1773/4885MAOB 951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.