Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.82 |
| ▸ | AR | P10275 | 1/20 | 0.74 |
| ▸ | CXCL12 | P48061 | 2/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.74 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | PDE4A | P27815 | 1/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL634099 | 0.93 | PDE4A (0.82) | CHRNA7ARMEN1KMT2ATDP1 | |
| SCHEMBL634098 | 0.93 | PDE4A (0.82) | CHRNA7ARMEN1KMT2ATDP1 | |
| SCHEMBL25197304 | 0.91 | ABCG2 (0.81) | CHRNA7CXCL12PTGS1PTGS2MEN1 | |
| SCHEMBL21527681 | 0.91 | ABCG2 (0.85) | CHRNA7CXCL12PTGS1PTGS2MEN1 | |
| SCHEMBL21527682 | 0.91 | ABCG2 (0.85) | CHRNA7CXCL12PTGS1PTGS2MEN1 | |
| SCHEMBL19783025 | 0.91 | ABCG2 (0.81) | CHRNA7CXCL12PTGS1PTGS2MEN1 | |
| SCHEMBL30383701 | 0.91 | ABCG2 (0.81) | CHRNA7CXCL12PTGS1PTGS2MEN1 | |
| SCHEMBL5137913 | 0.90 | CHRNA7 (1.00) | CHRNA7ARCXCL12PTGS1PTGS2 | |
| SCHEMBL5137911 | 0.90 | CHRNA7 (1.00) | CHRNA7ARCXCL12PTGS1PTGS2 | |
| SCHEMBL25327273 | 0.89 | MAPT (0.89) | MEN1KMT2ATDP1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9192589-B2 | Chalcones as enhancer of antimicrobial agents | COLGATE-PALMOLIVE COMPANY (US) | 2015-11-24 | — | — | US | claimed |
| EP-2512461-B1 | CHALCONES AS ENHANCER OF ANTIMICROBIAL AGENTS | COLGATE PALMOLIVE CO (US) | 2013-10-23 | — | — | EP | claimed |
| US-20120251464-A1 | CHALCONES AS ENHANCER OF ANTIMICROBIAL AGENTS | INDIAN INSTITUTE OF INTEGRATIVE MEDICINE (IN) | 2012-10-04 | — | — | US | claimed |
| US-9192589-B2 | Chalcones as enhancer of antimicrobial agents | COLGATE-PALMOLIVE COMPANY (US) | 2015-11-24 | — | — | US | disclosed |
| EP-2512461-B1 | CHALCONES AS ENHANCER OF ANTIMICROBIAL AGENTS | COLGATE PALMOLIVE CO (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-2512461-A1 | CHALCONES AS ENHANCER OF ANTIMICROBIAL AGENTS | Colgate-Palmolive Company (US) | 2012-10-24 | — | — | EP | disclosed |
| US-20120251464-A1 | CHALCONES AS ENHANCER OF ANTIMICROBIAL AGENTS | INDIAN INSTITUTE OF INTEGRATIVE MEDICINE (IN) | 2012-10-04 | — | — | US | disclosed |
| WO-2011075136-A1 | CHALCONES AS ENHANCER OF ANTIMICROBIAL AGENTS | COLGATE-PALMOLIVE COMPANY (US) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120251464-A1 | CHALCONES AS ENHANCER OF ANTIMICROBIAL AGENTS | LSS, CYP51A1, ELANE | CHRNA7 4873/4885AR 4049/4885CXCL12 1467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.