Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.82 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.82 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.82 |
| ▸ | RELA | Q04206 | 2/20 | 0.82 |
| ▸ | AR | P10275 | 2/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.73 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.70 |
| ▸ | MAOB | P27338 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5137911 | 1.00 | CHRNA7 (1.00) | CHRNA7MEN1KMT2ATDP1NFKB1 | |
| SCHEMBL2052875 | 0.90 | CHRNA7 (0.82) | CHRNA7MEN1KMT2ATDP1NFKB1 | |
| Homobutein SCHEMBL31028350 | 0.90 | MEN1 (1.00) | CHRNA7MEN1KMT2ATDP1NFKB1 | |
| Homobutein SCHEMBL633521 | 0.90 | MEN1 (1.00) | CHRNA7MEN1KMT2ATDP1NFKB1 | |
| SCHEMBL25195985 | 0.90 | MAOB (0.85) | CHRNA7MEN1KMT2ATDP1NFKB1 | |
| SCHEMBL25219851 | 0.90 | MAOB (0.85) | CHRNA7MEN1KMT2ATDP1NFKB1 | |
| Homobutein SCHEMBL633522 | 0.90 | MEN1 (1.00) | CHRNA7MEN1KMT2ATDP1NFKB1 | |
| Homobutein SCHEMBL25190880 | 0.90 | MEN1 (1.00) | CHRNA7MEN1KMT2ATDP1NFKB1 | |
| SCHEMBL5433329 | 0.88 | CHRNA7 (0.78) | CHRNA7MEN1KMT2ATDP1NFKB1 | |
| SCHEMBL5433332 | 0.88 | CHRNA7 (0.78) | CHRNA7MEN1KMT2ATDP1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017132135-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-03 | — | — | WO | disclosed |
| WO-2007115181-A9 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEM CO (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | EASTMAN CHEMICAL COMPANY | 2007-11-01 | — | — | US | disclosed |
| WO-2007115181-A2 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | ABCC4, NCOA4, NR4A3 | CHRNA7 684/4885MEN1 4281/4885KMT2A 4362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.