Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.82 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.82 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.82 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.82 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.81 |
| ▸ | FLT3 | P36888 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.75 |
| ▸ | AR | P10275 | 2/20 | 0.75 |
| ▸ | ACHE | P22303 | 1/20 | 0.72 |
| ▸ | MAOB | P27338 | 1/20 | 0.72 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL634098 | 1.00 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL2052875 | 0.93 | CHRNA7 (0.82) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL633910 | 0.91 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL633909 | 0.91 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL25199780 | 0.90 | ABCG2 (1.00) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL30382948 | 0.90 | ABCG2 (1.00) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL5082179 | 0.90 | ABCG2 (1.00) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL30384406 | 0.90 | ABCG2 (1.00) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL5082183 | 0.90 | ABCG2 (1.00) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL25327273 | 0.88 | MAPT (0.89) | ABCG2MAPTSMN1; SMN2ACHEMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190008797-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-01-10 | — | — | US | disclosed |
| WO-2017132135-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-03 | — | — | WO | disclosed |
| EP-1888174-B1 | USE OF CHALCONES FOR THE TREATMENT OF VIRAL DISORDERS | JOHNSON & JOHNSON CONSUMER (US) | 2012-02-22 | — | — | EP | disclosed |
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | EASTMAN CHEMICAL COMPANY | 2007-11-01 | — | — | US | disclosed |
| US-20060270614-A1 | Use of chalcones for the treatment of viral disorders | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | ABCC4, NCOA4, NR4A3 | PDE4A 1853/4885PDE4B 1669/4885PDE4C 3080/4885 |
| US-20060270614-A1 | Use of chalcones for the treatment of viral disorders | HAVCR2, HMGB3, EIF2AK2 | PDE4A 3695/4885PDE4B 3845/4885PDE4C 3869/4885 |
| US-20190008797-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | ESRRG, GPER1, ESR2 | PDE4A 1590/4885PDE4B 2973/4885PDE4C 2765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.